SCG10 Activators
SCG10 activators refer to a group of chemical entities designed to modulate the activity of the protein SCG10, also known as stathmin-like 2 (STMN2). SCG10 is known for its role in neuronal outgrowth and the regulation of the microtubule cytoskeleton, which is pivotal for the proper functioning and structural integrity of neurons. The activators of SCG10 might operate through direct or indirect mechanisms to enhance the protein's activity.
Direct activators interact with SCG10 at specific binding sites, inducing a conformational change that augments its affinity for microtubules or its ability to promote microtubule polymerization and stability. This can involve stabilizing the active form of SCG10 or disrupting its interaction with proteins that inhibit its activity. By binding to SCG10, direct activators facilitate its role in modulating microtubule dynamics, which is essential for processes such as axonal growth, guidance, and synaptic plasticity. Indirect activators, on the other hand, might function by upregulating the expression of the SCG10 gene, enhancing the translation of its mRNA, or decreasing the rate of degradation of the protein, thereby increasing its cellular levels. They could also affect the protein's activity through the modulation of upstream signaling pathways or post-translational modifications that control SCG10's function. For example, kinases that phosphorylate SCG10 might be activated by such compounds, altering the protein's interaction with microtubules or other binding partners.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates the TRPV1 channel, which leads to calcium influx. This process can trigger the calcium/calmodulin-dependent protein kinase (CaMK) pathway, known to phosphorylate SCG10 and enhance its microtubule-destabilizing activity. | ||||||
Nimodipine | 66085-59-4 | sc-201464 sc-201464A | 100 mg 1 g | $61.00 $307.00 | 2 | |
Nimodipine is an L-type calcium channel blocker. By increasing calcium concentration, it can indirectly lead to the activation of the calcium/calmodulin-dependent protein kinases (CaMKs) pathway, which phosphorylates SCG10 and enhances its activity. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a known microtubule-depolymerizing agent. SCG10 is a microtubule-destabilizing protein, so nocodazole's activity could enhance the functional activity of SCG10. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA can activate protein kinase C (PKC), a known kinase that phosphorylates SCG10 on specific residues, enhancing its microtubule-destabilizing activity. | ||||||
Cilnidipine | 132203-70-4 | sc-201485 sc-201485A | 10 mg 50 mg | $74.00 $284.00 | 1 | |
Cilnidipine is a dual L/N type calcium channel blocker. By increasing calcium concentration, it can indirectly lead to the activation of the CaMKs pathway, which phosphorylates and enhances the activity of SCG10. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent protein kinase inhibitor. It can inhibit kinases other than PKC and CaMK, thereby shifting the balance in favor of these two kinases, which can in turn phosphorylate and activate SCG10. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine is a microtubule-depolymerizing drug. Given SCG10's role in microtubule destabilization, vinblastine's activity could enhance the functional activity of SCG10. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin induces calcium influx from the ER by inhibiting the SERCA pump, which can activate the CaMK pathway. This pathway phosphorylates SCG10, enhancing its activity. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, creating a greater number of targets for SCG10. This could enhance the functional activity of SCG10. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine is a microtubule-depolymerizing agent. Given SCG10's role in microtubule destabilization, colchicine's activity could enhance the functional activity of SCG10. | ||||||