SATB2 Inhibitors
SATB2 inhibitors are a class of chemical compounds that target a specific protein known as SATB2, or Special AT-rich sequence-binding protein 2. SATB2 is a transcription factor that plays a crucial role in gene regulation and chromatin organization. It is primarily involved in controlling the expression of various genes related to cell differentiation, development, and tissue-specific functions. SATB2 is particularly important in the context of skeletal development and craniofacial formation, as it helps regulate the differentiation of osteoblasts (bone-forming cells) and odontoblasts (tooth-forming cells). SATB2 inhibitors, as the name suggests, are designed to interfere with the normal function of SATB2 by binding to it or modulating its activity, thereby influencing downstream gene expression and cellular processes.
The development of SATB2 inhibitors has gained significant attention in the field of molecular biology and genetics. Researchers are keenly interested in understanding how manipulating SATB2 activity can impact various biological processes, particularly those related to bone and tooth development. By inhibiting SATB2, these compounds provide a valuable tool for studying the molecular mechanisms underlying skeletal and craniofacial disorders. Furthermore, SATB2 inhibitors hold promise for uncovering strategies for conditions involving abnormal bone formation or craniofacial abnormalities. These inhibitors offer a means to explore the intricate web of gene regulation and cellular differentiation that SATB2 orchestrates, opening doors to a deeper understanding of these complex biological processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a cytidine analog that incorporates into DNA and RNA, leading to hypomethylation of DNA. The demethylation can modify gene expression patterns, potentially downregulating SATB2 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
As a cytidine analog similar to 5-azacytidine, Decitabine incorporates into DNA and results in its hypomethylation, which could influence SATB2 gene expression patterns. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that results in hyperacetylation of histones, altering chromatin structure and potentially downregulating the expression of specific genes including SATB2. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
This compound also acts as a histone deacetylase inhibitor, leading to changes in chromatin structure and potentially modulating gene expression, including the downregulation of SATB2. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid is a well-known histone deacetylase inhibitor, leading to altered gene expression profiles. It could potentially downregulate SATB2 expression through changes in chromatin structure. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea has been shown to inhibit DNA synthesis, and its effects on gene expression are complex and varied. It might have the potential to modulate SATB2 expression indirectly through its impact on cellular processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid is a metabolite of Vitamin A and plays a role in gene expression regulation. It could potentially influence SATB2 expression as part of broader changes in cellular differentiation and development. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can modulate various cellular pathways and has been shown to influence gene expression. While its potential effects on SATB2 are not well-characterized, it could play a role in modulating its expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Found in green tea, this compound has been shown to have various effects on gene expression and could potentially influence SATB2 levels as part of its broader impacts on cellular function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a component of turmeric, has been studied for its potential effects on gene expression and cellular pathways. While specific impacts on SATB2 are not well-defined, it could potentially modulate its expression. | ||||||