Sar1B Inhibitors
Sar1B inhibitors are chemical entities that can diminish the functional activity of Sar1B, a protein involved in COPII vesicle-mediated transport from the ER to the Golgi. These inhibitors cover categories like protein transport inhibitors (Brefeldin A, Monensin), PI3K inhibitors (Wortmannin, LY294002), retrograde transport inhibitor (Retro-2), dynamin inhibitor (Dynasore), clathrin-mediated endocytosis inhibitor (Pitstop 2), exocytosis inhibitor (Exo1), and protein kinase inhibitors (H89, Go6983, Genistein, Staurosporine). By inhibiting these specific cellular processes and signaling molecules, the inhibitors can influence Sar1B's function without directly blocking its activity.
Brefeldin A and Monensin disrupt protein transport, a process that Sar1B is directly involved in. By inhibiting protein transport, these compounds can disrupt the normal functioning of Sar1B. Similarly, Wortmannin and LY294002 are inhibitors of PI3K, an enzyme that produces PI3P, a phosphoinositide that Sar1B interacts with to recruit proteins to the membrane for vesicle formation. Inhibiting PI3K can therefore result in a reduction of Sar1B-dependent vesicle formation and transport. Retro-2, Dynasore, Pitstop 2, and Exo1 interfere with either retrograde transport, endocytosis, or exocytosis, all vital components of the overall vesicle transport system. By disrupting these processes, these compounds can indirectly affect the function of Sar1B
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A is a fungal metabolite that interferes with protein transport from the endoplasmic reticulum to the Golgi apparatus. Sar1B is a key player in the COPII vesicle-mediated transport system. By inhibiting protein transport, Brefeldin A can disrupt the normal functioning of Sar1B. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore antibiotic that disrupts intracellular transport processes. It can inhibit the function of Sar1B indirectly by disrupting the pH and ion balance that is necessary for proper vesicle formation and transport. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor. Sar1B has been shown to interact with PI3P, a product of PI3K, to recruit proteins to the membrane for vesicle formation. By inhibiting PI3K, Wortmannin can reduce Sar1B-dependent vesicle formation and transport. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor. By inhibiting PI3K, it can reduce the production of PI3P, thereby lowering Sar1B-mediated vesicle formation and transport. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore is a cell-permeable inhibitor of dynamin, a GTPase involved in endocytosis. Inhibition of endocytosis can disrupt the overall balance of vesicle transport, indirectly affecting the function of Sar1B. | ||||||
Pitstop 2 | 1419093-54-1 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 is a selective inhibitor of clathrin-mediated endocytosis. By inhibiting this process, it can disrupt the overall balance of vesicle transport and indirectly affect the function of Sar1B. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $82.00 $291.00 | 4 | |
Exo1 is a cell-permeable inhibitor of exocytosis. By inhibiting exocytosis, it can disrupt the balance of vesicle transport, indirectly affecting the function of Sar1B. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $92.00 $182.00 | 71 | |
H89 is a protein kinase A (PKA) inhibitor. PKA can phosphorylate proteins involved in vesicle transport. By inhibiting PKA, H89 may indirectly affect Sar1B-mediated vesicle transport. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go6983 is a broad-spectrum PKC inhibitor. PKC can phosphorylate proteins involved in vesicle transport. By inhibiting PKC, Go6983 may indirectly affect Sar1B-mediated vesicle transport. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a broad-spectrum tyrosine kinase inhibitor. Tyrosine kinases can phosphorylate proteins involved in vesicle transport. By inhibiting these kinases, Genistein may indirectly affect Sar1B-mediated vesicle transport. | ||||||