Salmonella O Inhibitors
Salmonella O Inhibitors constitute a class of chemicals that target the synthesis, transport, or stability of the O antigen in the bacterial outer membrane. These inhibitors work through various biochemical pathways to influence the function or presence of the O antigen, a crucial part of Salmonella's lipopolysaccharide (LPS) layer. For instance, 2-Deoxy-D-glucose inhibits glycosyltransferases that play an essential role in the biosynthesis of O-antigen sugars. Another compound, Tunicamycin, disrupts glycosylation by targeting the enzyme GlcNAc phosphotransferase. Both of these chemicals serve to limit the biosynthesis and structural integrity of the O antigen.
Similarly, chemicals like Fosfomycin, Rifampicin, and Chloramphenicol act indirectly but effectively. Fosfomycin inhibits MurA, impacting the peptidoglycan layer and, by extension, affecting the stability of the LPS layer where the O antigen resides. Rifampicin and Chloramphenicol impact the RNA and protein synthesis machinery of the bacteria, thereby affecting the formation of proteins essential for O antigen synthesis and transport. Compounds like Daptomycin and Valinomycin disrupt cellular energetics, affecting energy-dependent processes that are vital for the O antigen's transport and assembly. Therefore, Salmonella O Inhibitors offer a targeted approach to disrupting the biosynthesis, transport, and function of the O antigen.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
Inhibits glycosyltransferases involved in the biosynthesis of O-antigen sugars. It effectively limits the structural integrity of the O antigen, thereby indirectly affecting its function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Targets the enzyme GlcNAc phosphotransferase, disrupting the initial glycosylation step in O-antigen biosynthesis. | ||||||
Hygromycin B solution | 31282-04-9 | sc-29067 | 1 g | $104.00 | 40 | |
Inhibits protein synthesis by targeting the 30S ribosomal subunit. This disrupts the formation of proteins that are crucial for the biosynthesis and transport of the O antigen. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
Disrupts bacterial membrane potential. Affects the energy-dependent processes required for the transport and assembly of the O antigen. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Inhibits the 50S ribosomal subunit. Affects the synthesis of enzymes essential for the biosynthesis and transport of O antigen. | ||||||
Valinomycin | 2001-95-8 | sc-200991 | 25 mg | $250.00 | 3 | |
Acts as a potassium ionophore, disrupting cellular ionic balance. This indirectly influences the energy state of the cell, which is critical for the biosynthesis and transport of O antigen. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Inhibits bacterial RNA polymerase. Impacts the transcription of genes related to O antigen formation. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Targets the 50S ribosomal subunit and inhibits protein synthesis. This can inhibit the enzymes that catalyze O antigen biosynthesis. | ||||||
Kanamycin | 8063-07-8 | sc-492406 | 1 g | $500.00 | 3 | |
Inhibits the 30S ribosomal subunit. By inhibiting protein synthesis, it disrupts the formation of proteins needed for O antigen synthesis and transport. | ||||||
Azithromycin | 83905-01-5 | sc-254949 sc-254949A sc-254949B sc-254949C sc-254949D | 25 mg 50 mg 500 mg 1 g 5 g | $52.00 $103.00 $260.00 $364.00 $728.00 | 17 | |
Inhibits the 50S ribosomal subunit, affecting protein synthesis. Can inhibit the formation of enzymes that are necessary for O antigen biosynthesis and function. | ||||||