RRS1 Inhibitors
RRS1 inhibitors represent a class of chemical compounds specifically designed to target and modulate the function of the Ribosome Biogenesis Regulator 1 Homolog (RRS1) protein. Given the central role of RRS1 in the early steps of ribosome biogenesis, these inhibitors can profoundly influence the nucleolar processing of pre-18S ribosomal RNA and overall ribosome assembly.
The structural diversity of RRS1 inhibitors stems from their design to interact with various domains of the RRS1 protein or its interacting partners. These domains might include the regions of RRS1 that are involved in binding to rRNA or other ribosome biogenesis factors. By binding to these sites, RRS1 inhibitors can prevent the normal function of RRS1, thereby affecting the intricate process of ribosome formation. Some inhibitors might act by blocking the physical interactions between RRS1 and its partners, while others might influence its stability or localization within the cell. The specificity of these compounds is paramount, as off-target effects could lead to unwanted cellular outcomes. As with any class of chemical modulators, the efficacy, specificity, and selectivity of RRS1 inhibitors can vary widely, necessitating rigorous testing and validation in appropriate biological systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D inhibits RNA synthesis. Impaired RNA synthesis can lead to reduced expression of many genes, including RRS1, which is involved in ribosome biogenesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR, Rapamycin reduces protein synthesis and ribosome biogenesis. Reduced ribosome biogenesis might decrease the need for RRS1, leading to its reduced expression. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
By affecting purine synthesis and RNA production, Mycophenolic acid might reduce the expression of genes involved in ribosome biogenesis, such as RRS1. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide's inhibition of protein synthesis could lead to cellular stress responses that downregulate ribosome biogenesis genes like RRS1. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil's interference with RNA synthesis might reduce the expression of genes like RRS1 that play roles in ribosomal RNA processing. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
By causing DNA damage, Camptothecin might induce cellular responses that downregulate genes involved in growth and proliferation, including ribosome biogenesis genes like RRS1. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin's inhibition of protein synthesis could trigger cellular mechanisms that reduce the expression of ribosome biogenesis genes, such as RRS1. | ||||||
Homoharringtonine | 26833-87-4 | sc-202652 sc-202652A sc-202652B | 1 mg 5 mg 10 mg | $51.00 $123.00 $178.00 | 11 | |
Harringtonine affects protein synthesis, and its impact might lead to cellular responses that downregulate ribosome biogenesis genes, potentially including RRS1. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $163.00 $316.00 | 436 | |
Puromycin's effect on protein synthesis could lead to cellular stress responses that downregulate genes involved in ribosome biogenesis, including RRS1. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Though mainly a bacterial inhibitor, in eukaryotes, Chloramphenicol might induce stress responses that reduce the expression of ribosome biogenesis genes like RRS1. | ||||||