RPGRIP1 Inhibitors
RPGRIP1 Inhibitors are a class of compounds that can directly or indirectly decrease the functional activity of RPGRIP1. These inhibitors act by disrupting the cellular processes and signaling pathways that RPGRIP1 is involved in. For instance, Tunicamycin inhibits N-linked glycosylation, a post-translational modification that RPGRIP1 undergoes. This can lead to the production of improperly folded RPGRIP1 protein, which can be degraded by the cell, leading to functional inhibition. Cycloheximide, an inhibitor of protein synthesis, can decrease the amount of RPGRIP1 protein produced, thus indirectly reducing its functional activity. Similarly, MG-132 inhibits the proteasome, leading to accumulation of dysfunctional proteins that could interfere with the normal functioning of RPGRIP1.
On the other hand, some RPGRIP1 inhibitors act by disrupting the signaling pathways it is involved in. For example, Staurosporine, Genistein, and Wortmannin are inhibitors of protein kinases, tyrosine kinases, and PI3K, respectively. These kinases are regulators of the signaling pathways that RPGRIP1 participates in. Inhibition of these kinases disrupts the signaling processes, which can lead to functional inhibition of RPGRIP1. Furthermore, compounds like FK506 and Okadaic acid, which inhibit calcineurin and protein phosphatases, respectively, can also disrupt the signaling pathways RPGRIP1 is involved in, leading to its functional inhibition. Lastly, compounds such as Bafilomycin A1 and Brefeldin A, which inhibit vacuolar-type H+-ATPase and protein transport, respectively, can impair protein trafficking and disrupt the proper localization of RPGRIP1, leading to its functional inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin is an inhibitor of N-linked glycosylation, an essential post-translational modification in proteins. RPGRIP1 is known to undergo glycosylation. By inhibiting this process, Tunicamycin can lead to the production of improperly folded RPGRIP1 protein, which can be degraded by the cell, leading to functional inhibition. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Cycloheximide is an inhibitor of protein synthesis in eukaryotes. This compound, by inhibiting the protein translation process, can decrease the amount of RPGRIP1 protein produced, thus indirectly reducing its functional activity. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor. The proteasome is involved in the degradation of misfolded or damaged proteins. Inhibition of the proteasome by MG-132 can lead to accumulation of dysfunctional proteins that could interfere with the normal functioning of RPGRIP1. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. RPGRIP1 is involved in signal transduction processes that are regulated by kinases. Inhibition of these kinases by staurosporine can disrupt the signaling pathways RPGRIP1 is involved in, leading to its functional inhibition. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. Since RPGRIP1 is involved in signaling pathways regulated by tyrosine kinases, inhibition of these kinases by genistein can disrupt the signaling processes that RPGRIP1 is involved in, leading to its functional inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K, a kinase involved in multiple cellular processes. By inhibiting PI3K, Wortmannin can disrupt the PI3K-Akt pathway, a signaling pathway that RPGRIP1 could be involved in, leading to its functional inhibition. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose is an inhibitor of glycolysis. Since energy production is crucial for protein function, inhibiting glycolysis can indirectly affect the function of RPGRIP1 by limiting the energy available for its activities. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
FK506 is an immunosuppressant that inhibits calcineurin, a phosphatase involved in multiple signaling pathways. Since RPGRIP1 is involved in signal transduction processes, inhibition of calcineurin by FK506 can disrupt the signaling pathways that RPGRIP1 is involved in, leading to its functional inhibition. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. Since RPGRIP1 is involved in signaling pathways regulated by these phosphatases, inhibition of these enzymes can disrupt the signaling processes that RPGRIP1 is involved in, leading to its functional inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that can disrupt the PI3K-Akt signaling pathway. Since RPGRIP1 is potentially involved in this pathway, inhibition of PI3K by LY294002 can disrupt this pathway and inhibit the function of RPGRIP1. | ||||||