RPGRIP1 Antibody (C-9): sc-390341
- RPGRIP1 Antibody (C-9) is a mouse monoclonal IgG3 κ RPGRIP1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 44-57 near the N-terminus of RPGRIP1 of mouse origin
- RPGRIP1 Antibody (C-9) is recommended for detection of RPGRIP1 isoforms 1 and 2 of mouse and rat origin by WB, IP, IF and ELISA
- Anti-RPGRIP1 Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for RPGRIP1 Antibody (C-9) for WB applications. This reagent is now offered in a bundle with RPGRIP1 Antibody (C-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
QUICK LINKS
SEE ALSO...
RPGRIP1 Antibody (C-9) is a mouse monoclonal IgG3 antibody that detects RPGRIP1 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). RPGRIP1 (C-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RPGRIP1, also known as retinitis pigmentosa GTPase regulator interacting protein 1, plays a crucial role in the structure and function of photoreceptor cells in the retina. RPGRIP1 is essential for proper morphogenesis of photoreceptor outer segments, where RPGRIP1 localizes to the cilium and interacts with SEC16S, a protein involved in trafficking proteins to the outer segment. The structural integrity of RPGRIP1 is vital, as RPGRIP1 forms homodimers and elongated homopolymers, which are necessary for function. Mutations in RPGRIP1 can lead to severe retinal diseases, including Leber congenital amaurosis type 6 and cone-rod dystrophy type 13, both of which result in significant visual impairment. Understanding RPGRIP1 structure and function is essential for developing therapeutic strategies for these inherited retinal disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RPGRIP1 Antibody (C-9) References:
- Identification of a novel protein interacting with RPGR. | Boylan, JP. and Wright, AF. 2000. Hum Mol Genet. 9: 2085-93. PMID: 10958647
- The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors. | Roepman, R., et al. 2000. Hum Mol Genet. 9: 2095-105. PMID: 10958648
- Complete exon-intron structure of the RPGR-interacting protein (RPGRIP1) gene allows the identification of mutations underlying Leber congenital amaurosis. | Gerber, S., et al. 2001. Eur J Hum Genet. 9: 561-71. PMID: 11528500
- Species-specific subcellular localization of RPGR and RPGRIP isoforms: implications for the phenotypic variability of congenital retinopathies among species. | Mavlyutov, TA., et al. 2002. Hum Mol Genet. 11: 1899-907. PMID: 12140192
- Evidence of RPGRIP1 gene mutations associated with recessive cone-rod dystrophy. | Hameed, A., et al. 2003. J Med Genet. 40: 616-9. PMID: 12920076
- Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of Leber congenital amaurosis. | Pawlyk, BS., et al. 2010. Hum Gene Ther. 21: 993-1004. PMID: 20384479
- Evidence for RPGRIP1 gene as risk factor for primary open angle glaucoma. | Fernández-Martínez, L., et al. 2011. Eur J Hum Genet. 19: 445-51. PMID: 21224891
- Structural organization and expression pattern of the canine RPGRIP1 isoforms in retinal tissue. | Kuznetsova, T., et al. 2011. Invest Ophthalmol Vis Sci. 52: 2989-98. PMID: 21282582
- Ophthalmic and cone derived electrodiagnostic findings in outbred Miniature Long-haired Dachshunds homozygous for a RPGRIP1 mutation. | Busse, C., et al. 2011. Vet Ophthalmol. 14: 146-52. PMID: 21521437
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RPGRIP1 Antibody (C-9) | sc-390341 | 200 µg/ml | $322.00 | |||
RPGRIP1 Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-523497 | 200 µg Ab, 40 µg BP | $361.00 | |||
RPGRIP1 Antibody (C-9) AC | sc-390341 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RPGRIP1 Antibody (C-9) HRP | sc-390341 HRP | 200 µg/ml | $322.00 | |||
RPGRIP1 Antibody (C-9) FITC | sc-390341 FITC | 200 µg/ml | $336.00 | |||
RPGRIP1 Antibody (C-9) PE | sc-390341 PE | 200 µg/ml | $349.00 | |||
RPGRIP1 Antibody (C-9) Alexa Fluor® 488 | sc-390341 AF488 | 200 µg/ml | $364.00 | |||
RPGRIP1 Antibody (C-9) Alexa Fluor® 546 | sc-390341 AF546 | 200 µg/ml | $364.00 | |||
RPGRIP1 Antibody (C-9) Alexa Fluor® 594 | sc-390341 AF594 | 200 µg/ml | $364.00 | |||
RPGRIP1 Antibody (C-9) Alexa Fluor® 647 | sc-390341 AF647 | 200 µg/ml | $364.00 | |||
RPGRIP1 Antibody (C-9) Alexa Fluor® 680 | sc-390341 AF680 | 200 µg/ml | $364.00 | |||
RPGRIP1 Antibody (C-9) Alexa Fluor® 790 | sc-390341 AF790 | 200 µg/ml | $364.00 | |||
RPGRIP1 (C-9) Neutralizing Peptide | sc-390341 P | 100 µg/0.5 ml | $69.00 |