robo2 Inhibitors
Robo2 inhibitors form a varied category of chemicals aimed at hindering the function of Roundabout 2 (Robo2), a transmembrane receptor crucial for axon guidance and cell migration. Operating either directly on Robo2 or indirectly by modulating specific signaling pathways essential for Robo2 activation, these inhibitors present diverse strategies to impede Robo2-mediated cellular responses. A notable direct inhibitor, DAPT, targets the Notch signaling pathway by inhibiting γ-secretase, thereby suppressing Robo2 expression. Simultaneously, LDN-193189 directly inhibits Robo2 by disrupting the BMP signaling pathway through the inhibition of BMP type I receptors.
Indirect inhibitors, exemplified by Cyclopamine and SU5402, introduce alternative strategies. Cyclopamine and SU5402 interfere with the Hedgehog and FGFR signaling pathways, respectively, resulting in downstream modulation of Robo2 expression. A distinct class of indirect inhibitors includes aminoglycoside antibiotics like neomycin and gentamicin. These antibiotics operate by disrupting Robo2's interaction with cell surface glycosaminoglycans (GAGs), leading to diminished cell surface expression and impaired Robo2 signaling. Collectively, these inhibitors shed light on the intricate regulatory networks influencing Robo2 function. Whether through direct interference with Robo2 or indirect modulation of key signaling pathways, they offer diverse avenues for manipulating Robo2-mediated cellular responses.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT is a direct inhibitor of robo2 by targeting the Notch signaling pathway. It inhibits γ-secretase, a key enzyme in Notch activation, leading to the downregulation of robo2 expression. DAPT modulates cellular processes by influencing Notch signaling, resulting in the inhibition of robo2 and potential attenuation of its functions. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
LDN-193189 acts as a direct robo2 inhibitor by targeting the BMP signaling pathway. It inhibits BMP type I receptors, disrupting the BMP pathway and leading to the modulation of robo2 expression. LDN-193189 influences cellular processes by interfering with BMP signaling, providing a potential avenue for the inhibition of robo2-mediated functions. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL 327 serves as a direct robo2 inhibitor by targeting the MAPK/ERK pathway. It inhibits MEK, a kinase in the MAPK/ERK pathway, leading to the downregulation of robo2 expression. SL 327 modulates cellular processes by influencing MAPK/ERK signaling, resulting in the inhibition of robo2 and potential interference with its cellular functions. | ||||||
Cyclopamine | 4449-51-8 | sc-200929 sc-200929A | 1 mg 5 mg | $94.00 $208.00 | 19 | |
Cyclopamine is a direct robo2 inhibitor targeting the Hedgehog signaling pathway. It inhibits Smoothened, a key component of the Hedgehog pathway, leading to the downregulation of robo2 expression. Cyclopamine modulates cellular processes by influencing Hedgehog signaling, resulting in the inhibition of robo2 and potential interference with its cellular functions. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $63.00 $98.00 | 36 | |
SU5402 acts as a direct robo2 inhibitor by targeting the FGFR signaling pathway. It inhibits FGFR tyrosine kinase activity, leading to the downregulation of robo2 expression. SU5402 modulates cellular processes by interfering with FGFR signaling, resulting in the inhibition of robo2 and potential interference with its cellular functions. | ||||||
Gentamicin sulfate | 1405-41-0 | sc-203334 sc-203334A sc-203334F sc-203334B sc-203334C sc-203334D sc-203334E | 1 g 5 g 50 g 100 g 1 kg 2.5 kg 7.5 kg | $56.00 $179.00 $509.00 $725.00 $1836.00 $2652.00 $6248.00 | 3 | |
Gentamicin, serves as an indirect robo2 inhibitor by disrupting the function of cell surface glycosaminoglycans (GAGs). | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 is a direct robo2 inhibitor targeting the TGF-β signaling pathway. It inhibits the TGF-β type I receptor, leading to the downregulation of robo2 expression. SB431542 modulates cellular processes by interfering with TGF-β signaling, resulting in the inhibition of robo2 and potential interference with its cellular functions. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1-endo acts as a direct robo2 inhibitor by targeting the Wnt signaling pathway. It inhibits Tankyrase, a regulator of the Wnt pathway, leading to the downregulation of robo2 expression. IWR-1-endo modulates cellular processes by influencing Wnt signaling, resulting in the inhibition of robo2 and potential interference with its cellular functions. | ||||||
Purmorphamine | 483367-10-8 | sc-202785 sc-202785A | 1 mg 5 mg | $57.00 $184.00 | 18 | |
Purmorphamine is a direct robo2 inhibitor targeting the Hedgehog signaling pathway. It activates Smoothened, leading to the downregulation of robo2 expression. Purmorphamine modulates cellular processes by influencing Hedgehog signaling, resulting in the inhibition of robo2 and potential interference with its cellular functions. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Pyrvinium pamoate is a direct robo2 inhibitor targeting the Wnt signaling pathway. It inhibits Casein Kinase 1ε, a component of the Wnt pathway, leading to the downregulation of robo2 expression. Pyrvinium pamoate modulates cellular processes by interfering with Wnt signaling, resulting in the inhibition of robo2 and potential interference with its cellular functions. | ||||||