robo2 Activators
Robo2 activators constitute a diverse class of chemicals designed to enhance the function of Roundabout 2 (Robo2), a transmembrane receptor crucial for axon guidance and cell migration. These activators act either directly on Robo2 or indirectly through modulating specific signaling pathways crucial for Robo2 activation. Notable direct activators include Retinoic Acid and Tazarotene, all engaging specific pathways to upregulate robo2 expression. Retinoic Acid, a direct activator, influences the retinoic acid signaling pathway by binding to retinoic acid receptors, resulting in the augmentation of robo2 expression. Similarly, Sonic Hedgehog directly activates robo2 by engaging the Hedgehog signaling pathway, offering a targeted approach to enhance Robo2-mediated cellular responses. Tazarotene, acting through the retinoic acid signaling pathway, serves as a retinoid receptor-selective prodrug, leading to the upregulation of robo2 expression.
Several indirect activators, such as Shh Antagonist 4 and Shh Agonist (Cur61414), modulate robo2 function by influencing the Hedgehog signaling pathway. Shh Antagonist 4 inhibits the Hedgehog pathway antagonist, Smoothened, indirectly enhancing Hedgehog signaling and subsequently upregulating robo2 expression. Shh Agonist (Cur61414) directly activates robo2 through Smoothened activation within the Hedgehog pathway. These activators collectively showcase the intricate regulatory networks influencing Robo2 function. Whether through direct engagement with Robo2 or indirect modulation of key signaling pathways, these activators offer diverse strategies to enhance Robo2-mediated cellular responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid serves as a direct activator of robo2 by influencing the retinoic acid signaling pathway. It binds to retinoic acid receptors, leading to the upregulation of robo2 expression. Retinoic acid modulates cellular processes by directly activating robo2 through the retinoic acid signaling pathway, offering a specific mechanism for enhancing robo2-mediated cellular responses. | ||||||
Tazarotene | 118292-40-3 | sc-220193 | 10 mg | $103.00 | ||
Tazarotene serves as a direct activator of robo2 through the retinoic acid signaling pathway. It is a retinoid receptor-selective prodrug that, upon activation, upregulates robo2 expression. Tazarotene modulates cellular processes by directly activating robo2 through the retinoic acid signaling pathway, offering a specific mechanism for enhancing robo2-mediated cellular responses. | ||||||
SAG | 912545-86-9 | sc-212905 sc-212905A | 1 mg 5 mg | $166.00 $421.00 | 27 | |
SAG1 acts as a direct robo2 activator by engaging the Hedgehog signaling pathway. It activates Smoothened, leading to the upregulation of robo2 expression. SAG1 modulates cellular processes by directly activating robo2 through the Hedgehog signaling pathway, offering a specific mechanism for enhancing robo2-mediated cellular responses. | ||||||
AM 80 | 94497-51-5 | sc-203816 sc-203816A | 10 mg 50 mg | $155.00 $620.00 | 1 | |
AM 80 is a direct activator of robo2 through the retinoic acid signaling pathway. It binds to retinoic acid receptors, leading to the upregulation of robo2 expression. AM 80 modulates cellular processes by directly activating robo2 through the retinoic acid signaling pathway, providing a specific mechanism for enhancing robo2-mediated cellular responses. | ||||||
SANT-1 | 304909-07-7 | sc-203253 | 5 mg | $135.00 | 5 | |
SANT-1 serves as an indirect activator of robo2 by inhibiting the Hedgehog pathway antagonist, Smoothened. By blocking Smoothened, SANT-1 enhances Hedgehog signaling, resulting in the upregulation of robo2 expression. | ||||||
CUR 61414 | 334998-36-6 | sc-211143 | 1 mg | $380.00 | 1 | |
Shh Agonist (Cur61414) is a direct robo2 activator that engages the Hedgehog signaling pathway. It activates Smoothened, leading to the upregulation of robo2 expression. Shh Agonist (Cur61414) modulates cellular processes by directly activating robo2 through the Hedgehog signaling pathway, offering a specific mechanism for enhancing robo2-mediated cellular responses. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
13-cis-Retinoic acid serves as a direct activator of robo2 through the retinoic acid signaling pathway. It binds to retinoic acid receptors, leading to the upregulation of robo2 expression. | ||||||