Molecular structure of Purmorphamine, CAS Number: 483367-10-8
Purmorphamine (CAS 483367-10-8)
See product citations (18)
Alternate Names:
2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-cyclohexyl-N-[4-(morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Application:
Purmorphamine is An activator of the hedgehog (Hh) signaling pathway
CAS Number:
483367-10-8
Purity:
≥98%
Molecular Weight:
520.62
Molecular Formula:
C31H32N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Purmorphamine, a purine derivative, may act to activate the Hedgehog (Hh) signaling pathway which is important for regulating embryonic patterning, stem cell renewal, and tissue regeneration. Additionally, this compound has been noted to display osteogenesis-inducing activity in multipotent mesenchymal progenitor cells. Similar studies have reported purmorphamine to enhance events related to osteoblast differentiation. Purmorphamine is an activator of Smo.
Purmorphamine (CAS 483367-10-8) References
- Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway. | Wu, X., et al. 2004. Chem Biol. 11: 1229-38. PMID: 15380183
- Tissue repair and stem cell renewal in carcinogenesis. | Beachy, PA., et al. 2004. Nature. 432: 324-31. PMID: 15549094
- The effect of purmorphamine on osteoblast phenotype expression of human bone marrow mesenchymal cells cultured on titanium. | Beloti, MM., et al. 2005. Biomaterials. 26: 4245-8. PMID: 15683647
- Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. | Beloti, MM., et al. 2005. Cell Biol Int. 29: 537-41. PMID: 15979909
- Purmorphamine activates the Hedgehog pathway by targeting Smoothened. | Sinha, S. and Chen, JK. 2006. Nat Chem Biol. 2: 29-30. PMID: 16408088
- Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway. | El-Akabawy, G., et al. 2011. Stem Cells Dev. 20: 1873-87. PMID: 21345011
- Cell attachment and response to photocured, degradable bone adhesives containing tricalcium phosphate and purmorphamine. | Gellynck, K., et al. 2011. Acta Biomater. 7: 2672-7. PMID: 21354477
- Hedgehog signaling and osteoblast gene expression are regulated by purmorphamine in human mesenchymal stem cells. | Oliveira, FS., et al. 2012. J Cell Biochem. 113: 204-8. PMID: 21898541
- The effect of purmorphamine and sirolimus on osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. | Faghihi, F., et al. 2013. Biomed Pharmacother. 67: 31-8. PMID: 23228449
- Purmorphamine increased adhesion, proliferation and expression of osteoblast phenotype markers of human dental pulp stem cells cultured on beta-tricalcium phosphate. | Rezia Rad, M., et al. 2016. Biomed Pharmacother. 82: 432-8. PMID: 27470382
- Purmorphamine as a Shh Signaling Activator Small Molecule Promotes Motor Neuron Differentiation of Mesenchymal Stem Cells Cultured on Nanofibrous PCL Scaffold. | Bahrami, N., et al. 2017. Mol Neurobiol. 54: 5668-5675. PMID: 27629890
- Directed transdifferentiation of Müller glial cells to photoreceptors using the sonic hedgehog signaling pathway agonist purmorphamine. | Gu, D., et al. 2017. Mol Med Rep. 16: 7993-8002. PMID: 28983586
- Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism. | Rahi, S., et al. 2021. Hum Exp Toxicol. 40: 1880-1898. PMID: 33906504
- Smo-Shh Agonist Purmorphamine Prevents Neurobehavioral and Neurochemical Defects in 8-OH-DPAT-Induced Experimental Model of Obsessive-Compulsive Disorder. | Gupta, R., et al. 2022. Brain Sci. 12: PMID: 35326298
- Teratogen-mediated inhibition of target tissue response to Shh signaling. | Cooper, MK., et al. 1998. Science. 280: 1603-7. PMID: 9616123
Inhibitor of:
1810043G02Rik, DAZ Interacting Zinc Finger Proteins (DZIP), DCHS2, GDNF, IFT140, IFT80, INTU, KIAA0586, robo2, TMEM216, TTC21B, WDR11, WDR35, and Zic5.Activator of:
achaete, BMP-3, BMPR-IA, Chibby, cubitus interruptus, Dhh, DISP1, DISP2, Distal-less, DZIP1, DZIP1L, EVC, EVC2, FAM83D, Fat, GLI-2, GLI-3, glypican-6, hedgehog, HH, HHAT, HMX3_Hmx3, HoxA7, HoxA9, IFT172, IFT81, IL-5, IRX4, KIAA1822L, KIF26B, LRP5L, Ly-55A, MAB21L1, MACS1, MESP2, nephrocystin-2, Neuron navigator 2, Nkx-2.2, patched 2, PHYHIP, PTCHD1, PTCHD2, PTCHD3, PTCHD4, Rab L4, SCUBE3, Shh, Six3, Smo, smoothened, STK36, Su(fu), Transferrinm Solution, and VWC1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Purmorphamine, 1 mg | sc-202785 | 1 mg | $56.00 | |||
Purmorphamine, 5 mg | sc-202785A | 5 mg | $180.00 |