RNF8 Inhibitors
RNF8 inhibitors comprises compounds that indirectly inhibit the activity of RNF8 by influencing various aspects of the DNA damage response and repair pathways. RNF8 is a crucial protein in orchestrating the cellular response to DNA damage, and its activity is regulated by a complex network of upstream signaling molecules, including kinases like ATM, ATR, DNA-PK, and others. Firstly, a significant characteristic of these chemicals is their targeted inhibition of key kinases within the DNA damage response pathways. Compounds like KU-55933, VE-821, and NU7026 inhibit ATM, ATR, and DNA-PK, respectively, thereby disrupting the signaling cascade that leads to the recruitment and activation of RNF8 at sites of DNA damage. This disruption results in the indirect inhibition of RNF8's role in mediating DNA repair processes.
Secondly, other members of this class, such as Olaparib and Niraparib, are PARP inhibitors that alter the broader landscape of DNA repair mechanisms. By impacting these mechanisms, these inhibitors can indirectly influence the activity of RNF8, given its role in the DNA damage response. Additionally, inhibitors of cell cycle kinases like CDK4/6 and CHK1/CHK2 also contribute to the modulation of RNF8 activity by affecting the upstream regulatory processes that control the cellular response to DNA damage. In conclusion, RNF8 inhibitors encompass a diverse array of compounds that indirectly inhibit RNF8 by targeting various components of the DNA damage response and repair pathways. These compounds act through the inhibition of key kinases and enzymes that regulate the upstream signaling events leading to RNF8 activation, thereby modulating its function in the context of DNA repair and cellular response to genomic insults.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
ATM Kinase Inhibitor can disrupt the signaling cascade leading to RNF8 recruitment and activation at DNA damage sites, thereby indirectly inhibiting RNF8 function. | ||||||
DNA-PK Inhibitor II | 154447-35-5 | sc-202143 sc-202143A | 10 mg 50 mg | $155.00 $660.00 | 6 | |
DNA-PK Inhibitor II can lead to impaired recruitment or activation of downstream effectors like RNF8, thus indirectly inhibiting its function. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
VE-821 targets ATR kinase, which is involved in the cellular response to DNA damage. Inhibition of ATR can affect the signaling pathways that regulate RNF8, potentially leading to its reduced activity in DNA repair processes. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $206.00 $299.00 $485.00 | 10 | |
Olaparib, a PARP inhibitor, can alter the DNA damage response and repair pathways. While primarily used for inhibiting PARP, its effect on DNA repair processes can indirectly influence RNF8 activity by altering the cellular response to DNA damage. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is an inhibitor of PI3K, and by extension, it affects the PI3K-related kinases involved in the DNA damage response, such as ATM and DNA-PK. This can lead to a downstream reduction in RNF8 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Similar to wortmannin, LY294002 inhibits PI3K and can consequently impact the kinases involved in DNA damage signaling. The inhibition of these kinases can indirectly reduce RNF8 function. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
PD0332991 inhibits CDK4/6, which are involved in cell cycle regulation. Its effect on the cell cycle can indirectly influence DNA damage response pathways and potentially reduce RNF8 activity. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762 inhibits CHK1, a kinase in the DNA damage response pathway. Inhibiting CHK1 can disrupt the activation of downstream effectors in DNA repair, including RNF8. | ||||||
MRN-ATM Pathway Inhibitor, Mirin | 299953-00-7 | sc-203144 | 10 mg | $138.00 | 4 | |
Mirin inhibits MRE11, a component of the MRN complex involved in the DNA damage response. Inhibiting MRE11 can affect the recruitment and activation of RNF8 at sites of DNA damage. | ||||||
ATM/ATR Kinase Inhibitor Inhibitor | 905973-89-9 | sc-202964 | 5 mg | $104.00 | 8 | |
By targeting these kinases, ATM/ATR Kinase Inhibitor can comprehensively disrupt the signaling pathways that activate RNF8 following DNA damage. | ||||||