RNF43 Activators
RNF43 activators comprise a group of chemicals that, directly or indirectly, modulate the activity of the RNF43 protein. Central to the function of RNF43 is its regulatory role within the Wnt signaling pathway. By ubiquitinating Frizzled receptors, RNF43 reduces Wnt signaling. The significance of this reduction is underscored by the plethora of chemicals that inhibit the Wnt pathway and, in doing so, could foster an environment for enhanced RNF43 activity. Chemicals like Salinomycin, XAV-939, and IWP-2 act as inhibitors to the Wnt pathway, presenting a scenario where RNF43's activity could be elevated to further repress the pathway.
Furthermore, while direct activation of RNF43 by these chemicals might not always be evident, the intricate interplay within the Wnt signaling framework suggests a level of indirect modulation. Chemicals like LGK-974, which inhibits Porcupine, an enzyme necessary for Wnt ligand secretion, or Roscovitine, which affects Wnt signaling, help illustrate this intricate dance of modulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $162.00 $241.00 $406.00 $474.00 | 1 | |
It can inhibit the Wnt pathway, potentially leading to increased RNF43 activity. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
Inhibits Wnt signaling by promoting β-catenin degradation; can increase RNF43's effects. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
Inhibits Wnt processing, which can indirectly activate RNF43 by limiting Wnt ligands. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
Stabilizes Axin by inhibiting the poly-ADP-ribosylating enzymes tankyrase 1 and 2. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
It is a Porcupine inhibitor, which can reduce Wnt signaling, indirectly affecting RNF43. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $260.00 | ||
It is a Wnt/β-catenin inhibitor, which may elevate RNF43's activity in the pathway. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
This is an anti-helminthic that also inhibits Wnt/β-catenin signaling. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $228.00 $422.00 | ||
Affects Wnt signaling, potentially leading to enhanced RNF43 activity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Can decrease Wnt signaling, potentially implicating a role for RNF43. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Known to modulate Wnt signaling, potentially having an indirect effect on RNF43 activity. | ||||||