RNF103-CHMP3 Activators
The functional activity of the RNF103-CHMP3 fusion protein can be influenced by a range of chemical compounds that target the distinct functionalities of the RNF103 and CHMP3 gene products. MG132 and Bortezomib, both proteasome inhibitors, could affect protein degradation pathways, potentially influencing the RNF103 component of the fusion protein, which is involved in ubiquitin-mediated protein degradation processes. Curcumin and Epigallocatechin gallate (EGCG), with their effects on various cellular signaling pathways, including those related to proliferation and apoptosis, could impact both RNF103 and CHMP3 components, potentially influencing processes such as protein trafficking and cell signaling. Resveratrol, by activating SIRT1, could support the CHMP3 component's role in endosomal-lysosomal pathways within the fusion protein, influencing gene expression and cellular aging processes.
Rapamycin, an inhibitor of mTOR, could modulate autophagy and cell growth pathways, affecting the functionality of both RNF103 and CHMP3 components, particularly in autophagy and protein trafficking. Genistein, a tyrosine kinase inhibitor, might affect the CHMP3 component, particularly in endosomal-lysosomal function. 17-AAG (Tanespimycin), an HSP90 inhibitor, could indirectly influence the stability and function of the CHMP3 component. LY294002, a PI3K inhibitor, and Trichostatin A, an HDAC inhibitor, could also affect cellular signaling and gene expression, potentially influencing both components of the fusion protein. Forskolin, by increasing cAMP levels, might influence the RNF103 component, particularly in ubiquitin-mediated processes. Spermidine, promoting autophagy, may support the CHMP3 component's role in this process within the fusion protein. Collectively, these compounds demonstrate the complexity in modulating the activity of the RNF103-CHMP3 fusion protein, reflecting the diverse functional aspects and regulatory mechanisms of its constituent parts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can affect protein degradation pathways. This might influence the RNF103 component of the RNF103-CHMP3 fusion protein, potentially affecting ubiquitin-mediated protein degradation processes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib, another proteasome inhibitor, can affect protein degradation pathways, potentially influencing both RNF103 and CHMP3 components of the fusion protein, particularly in pathways related to cell signaling and apoptosis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates various signaling pathways, including those involved in cell proliferation and apoptosis. This could affect both RNF103 and CHMP3 components of the fusion protein, influencing cellular processes such as protein trafficking. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) modulates several signaling pathways, including those related to cell proliferation and apoptosis. EGCG could influence both components of the fusion protein in cellular signaling processes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, influencing gene expression and cellular aging processes. This could support the CHMP3 component's role in endosomal-lysosomal pathways in the RNF103-CHMP3 fusion protein. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, involved in cell growth and autophagy. This inhibition could influence the functions of both RNF103 and CHMP3 components in the fusion protein, particularly in pathways related to autophagy and protein trafficking. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can modulate cell signaling pathways. This might affect the CHMP3 component of the RNF103-CHMP3 fusion, particularly in pathways related to endosomal-lysosomal function. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is an HSP90 inhibitor that can affect protein folding and stability. It might indirectly influence the stability and function of the CHMP3 component of the fusion protein. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a PI3K inhibitor, could influence cellular signaling pathways related to cell survival and proliferation, potentially affecting both RNF103 and CHMP3 components of the fusion protein. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is an HDAC inhibitor, affecting gene expression and protein acetylation. This could influence the function of both RNF103 and CHMP3 in the fusion protein. | ||||||