RNase HII-B Activators
Ribonuclease H2, subunit B (RNase H2B), is an essential component of the RNase H2 enzyme complex, which plays a pivotal role in DNA replication and repair. Specifically, RNase H2B contributes to the excision of ribonucleotide monophosphates (rNMPs) embedded in DNA, an activity crucial for maintaining genomic stability. The RNase H2 complex is unique in its ability to recognize and cleave these rNMPs from DNA/RNA hybrids and is involved in the DNA replication process by removing the RNA primers and initiating Okazaki fragment maturation.
Mutations in the gene coding for RNase H2B can lead to a rare autosomal recessive disorder known as Aicardi-Goutières syndrome (AGS), characterized by early-onset encephalopathy and chronic cerebrospinal inflammation, highlighting the enzyme's significance in immune response regulation and neurological development.RNase H2B's activity is not confined to the nucleus; it also localizes to the mitochondria, indicating a role in mitochondrial DNA replication and repair. Its function is integral to the blocking of genome instability, which is a hallmark of aging and many diseases. The enzyme operates in a coordinated manner with other repair and replication machinery, ensuring the integrity of the genetic material is preserved during cell division.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
As a DNA methyltransferase inhibitor, it could potentially upregulate genes by causing DNA hypomethylation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is a histone deacetylase inhibitor, potentially relaxing chromatin and enhancing gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA, another histone deacetylase inhibitor, could increase transcription by affecting chromatin accessibility. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $129.00 $284.00 $1004.00 | 3 | |
Zebularine acts as a DNA methyltransferase inhibitor, potentially promoting gene expression by demethylation of gene promoter regions. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $131.00 $515.00 | 2 | |
RG108, a non-nucleoside DNA methyltransferase inhibitor, may lead to increased gene expression by preventing methylation. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Disulfiram can modulate gene expression indirectly through its influence on metal ion homeostasis. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, might modulate gene expression via signal transduction pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can influence gene expression through its action on sirtuin signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may affect gene expression through its role as a transcription factor modulator. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate can induce changes in chromatin structure and gene expression. | ||||||