RMP Activators
RMP Activators are a diverse class of chemical compounds, all of which are capable of enhancing the functional activity of the RMP protein, with most doing so through specific signaling pathways. Forskolin and Isoproterenol, for instance, enhance RMP activity via the cAMP-PKA pathway. These two compounds stimulate adenylate cyclase, leading to an increase in cAMP levels. The elevated cAMP then activates PKA, which phosphorylates RMP, enhancing its activity. Similarly, the compounds 8-Bromo-cAMP, Rolipram, Sp-cAMP, Cilostamide, and Milrinone also operate via the cAMP-PKA pathway but through different mechanisms, such as inhibiting phosphodiesterase enzymes or acting as cAMP analogs.
In contrast, Phorbol 12-myristate 13-acetate (PMA) and Calyculin A operate via the protein kinase C and protein phosphatase pathways, respectively. PMA is a direct activator of PKC, which can phosphorylate and activate RMP. On the other hand, Calyculin A, Okadaic Acid, and H-89 maintain RMP in an activated state by inhibiting protein phosphatases, preventing the dephosphorylation of RMP. Finally, Erythro-9-(2-Hydroxy-3-nonyl) adenine (EHNA) enhances RMP function by inhibiting adenosine deaminase and PDE2, thereby increasing cAMP levels.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin enhances RMP function by activating adenylate cyclase, which increases cyclic AMP (cAMP) levels. Elevated cAMP can activate protein kinase A (PKA), which phosphorylates and enhances the activity of RMP. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that activates G-proteins, leading to adenylate cyclase activation, increased cAMP, PKA activation and, ultimately, RMP activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a direct activator of protein kinase C (PKC), which can phosphorylate RMP, enhancing its activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA and can enhance RMP function. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram inhibits phosphodiesterase 4 (PDE4), increasing intracellular cAMP levels, which can activate PKA and enhance RMP activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases (PP1 and PP2A), preventing RMP dephosphorylation and thereby maintaining RMP in an activated state. | ||||||
Sp-cAMPS | 93602-66-5 | sc-201571 | 1 mg | $97.00 | 3 | |
Sp-cAMP is a cell-permeable, PKA-activating cAMP analog that can enhance RMP function. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $92.00 $357.00 | 16 | |
Cilostamide is a PDE3 inhibitor that can increase cAMP levels, leading to PKA activation and enhanced RMP activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases (PP1 and PP2A), preventing RMP dephosphorylation and maintaining its activated state. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $165.00 $697.00 | 7 | |
Milrinone is a PDE3 inhibitor that can increase cAMP levels, leading to PKA activation and enhanced RMP activity. | ||||||