RMP Antibody (D-2): sc-376011
- RMP Antibody (D-2) is a mouse monoclonal IgG1 κ RMP antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-240 mapping at the N-terminus of RMP of human origin
- RMP Antibody (D-2) is recommended for detection of RMP of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-RMP Antibody (D-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-376011 X, 200 µg/0.1 ml)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for RMP Antibody (D-2) for WB and IHC(P) applications. These reagents are now offered in bundles with RMP Antibody (D-2) (see ordering information below).
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RMP Antibody (D-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects RMP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). RMP antibody (D-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. RMP protein, also known as RPB5-mediating protein, C19orf2, or URI, is a 534 amino acid protein predominantly localized in the nucleus, where RMP plays a crucial role in the assembly of the multi-protein URI complex. This complex is essential for various cellular processes, including transcription regulation and protein ubiquitination, highlighting RMP′s importance in gene expression and protein turnover. The presence of multiple isoforms of RMP, resulting from alternative splicing, adds another layer of complexity to RMP′s function and regulation. The gene encoding RMP is located on human chromosome 19, a region known for its high gene density, containing approximately 1,400 genes within over 63 million bases. RMP antibody (D-2) is an invaluable tool for researchers studying the intricate roles of RMP in cellular mechanisms and potential implications in various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
RMP Antibody (D-2) References:
- Interaction with general transcription factor IIF (TFIIF) is required for the suppression of activated transcription by RPB5-mediating protein (RMP). | Wei, W., et al. 2003. Cell Res. 13: 111-20. PMID: 12737519
- Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. | Gstaiger, M., et al. 2003. Science. 302: 1208-12. PMID: 14615539
- Subcellular localization of RPB5-mediating protein and its putative functional partner. | Delgermaa, L., et al. 2004. Mol Cell Biol. 24: 8556-66. PMID: 15367675
- S6K1-mediated disassembly of mitochondrial URI/PP1gamma complexes activates a negative feedback program that counters S6K1 survival signaling. | Djouder, N., et al. 2007. Mol Cell. 28: 28-40. PMID: 17936702
- RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. | Dorjsuren, D., et al. 1998. Mol Cell Biol. 18: 7546-55. PMID: 9819440
- Molecular cloning of a gene on chromosome 19q12 coding for a novel intracellular protein: analysis of expression in human and mouse tissues and in human tumor cells, particularly Reed-Sternberg cells in Hodgkin disease. | Van Leuven, F., et al. 1998. Genomics. 54: 511-20. PMID: 9878255
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RMP Antibody (D-2) | sc-376011 | 200 µg/ml | $322.00 | |||
RMP Antibody (D-2): m-IgG Fc BP-HRP Bundle | sc-529800 | 200 µg Ab; 10 µg BP | $361.00 | |||
RMP Antibody (D-2): m-IgGκ BP-HRP Bundle | sc-522817 | 200 µg Ab, 40 µg BP | $361.00 | |||
RMP Antibody (D-2): m-IgG1 BP-HRP Bundle | sc-543693 | 200 µg Ab; 20 µg BP | $361.00 | |||
RMP Antibody (D-2) X | sc-376011 X | 200 µg/0.1 ml | $322.00 | |||
RMP Antibody (D-2) AC | sc-376011 AC | 500 µg/ml, 25% agarose | $424.00 | |||
RMP Antibody (D-2) HRP | sc-376011 HRP | 200 µg/ml | $322.00 | |||
RMP Antibody (D-2) FITC | sc-376011 FITC | 200 µg/ml | $336.00 | |||
RMP Antibody (D-2) PE | sc-376011 PE | 200 µg/ml | $349.00 | |||
RMP Antibody (D-2) Alexa Fluor® 488 | sc-376011 AF488 | 200 µg/ml | $364.00 | |||
RMP Antibody (D-2) Alexa Fluor® 546 | sc-376011 AF546 | 200 µg/ml | $364.00 | |||
RMP Antibody (D-2) Alexa Fluor® 594 | sc-376011 AF594 | 200 µg/ml | $364.00 | |||
RMP Antibody (D-2) Alexa Fluor® 647 | sc-376011 AF647 | 200 µg/ml | $364.00 | |||
RMP Antibody (D-2) Alexa Fluor® 680 | sc-376011 AF680 | 200 µg/ml | $364.00 | |||
RMP Antibody (D-2) Alexa Fluor® 790 | sc-376011 AF790 | 200 µg/ml | $364.00 |