RINZF Activators
RINZF Activators encompass a range of chemical compounds that enhance the functional activity of RINZF through distinct signaling pathways and molecular interactions. For instance, Forskolin and Sildenafil both elevate intracellular cAMP levels, thus enhancing PKA activation, which is known to phosphorylate transcription factors and improve their DNA-binding affinity; this phosphorylation can directly enhance the transcriptional regulatory functions of RINZF. Similarly, by activating Nrf2 signaling, Sulforaphane indirectly bolsters RINZF activity by preparing the cellular antioxidative environment, which could affect RINZF's gene regulatory network. Curcumin and Resveratrol activate JAK/STAT and SIRT1 pathways, respectively, which can promote RINZF's gene regulation by enhancing its DNA binding and stability. Trichostatin A alters chromatin accessibility, potentially allowing RINZF greater access to DNA for transcriptional regulation. Lithium Chloride's inhibition of GSK-3 and the consequent activation of β-catenin might amplify RINZF's transcriptional output by facilitating cooperative gene regulation.
Additionally, activators such as Retinoic Acid, Pioglitazone, and Vitamin D3 operate through nuclear receptor pathways, forming complexes with RARs, PPARγ, and VDR, respectively. These complexes can interact with RINZF, potentially augmenting its transcriptional activity by promoting cooperative interactions at gene promoters. Omega-3 Fatty Acids, by altering membrane dynamics and receptor activities, indirectly affect signaling pathways that RINZF is a part of, hence modulating its functional activity within the cell's gene regulatory networks. Lastly, Epigallocatechin Gallate's inhibition of NF-κB provides a less competitive environment for RINZF at the DNA level, facilitating an enhanced gene regulatory role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin acts by directly stimulating adenylyl cyclase, leading to increased production of cAMP. The elevation of cAMP activates PKA, which in turn can phosphorylate and enhance the activity of RINZF by promoting its nuclear localization and DNA-binding capacity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2 signaling by modifying Keap1, leading to the transcriptional activation of antioxidant response element (ARE)-mediated genes. Nrf2 activation can indirectly enhance RINZF activity by modulating the oxidative stress response and potentially altering RINZF's gene regulatory network. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates the JAK/STAT signaling pathway, which is involved in cell signaling related to growth and apoptosis. Activation of this pathway can lead to enhanced transcription factor activity, including RINZF, by promoting its DNA binding and gene regulatory functions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which modulates cellular processes including DNA repair and gene expression. The activation of SIRT1 can enhance RINZF activity through deacetylation, influencing its stability and interaction with target gene promoters. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, changes chromatin structure, increasing accessibility to transcription factors. This can enhance RINZF activity by improving its access to chromatin and facilitating its transcriptional regulation of gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3, leading to the stabilization and activation of β-catenin. Activated β-catenin enters the nucleus and can cooperate with RINZF in gene regulation, potentially enhancing RINZF-mediated transcriptional activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid binds to retinoic acid receptors (RARs), which heterodimerize with RXRs, affecting gene transcription. The activation of these receptors can lead to an enhanced RINZF activity through cooperative interaction at gene regulatory regions. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone is a PPARγ agonist that modulates gene expression related to glucose and lipid metabolism. PPARγ activation can enhance RINZF activity by influencing the chromatin landscape and improving RINZF's access to its target genes. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Vitamin D3 through its active metabolite, calcitriol, binds to the vitamin D receptor (VDR), which can heterodimerize with RXR, influencing gene expression. VDR activation can enhance the activity of RINZF by facilitating its interaction with gene promoters in a cooperative manner. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate is known to inhibit NF-κB signaling, which competes with and can repress transcription factors including RINZF. By inhibiting NF-κB, it may enhance RINZF's ability to bind to DNA and regulate gene expression without competition from NF-κB. | ||||||