RINZF Inhibitors
Chemical inhibitors of RINZF can exert their inhibitory effects through various cellular and molecular mechanisms. Alsterpaullone targets cyclin-dependent kinases (CDKs), enzymes that are essential for the regulation of the cell cycle and transcription. By inhibiting CDKs, Alsterpaullone can decrease the availability of transcription factors that are necessary for RINZF function, leading to its functional inhibition. Similarly, Y-27632 acts upon the Rho-associated protein kinase (ROCK), a key player in the RhoA/ROCK signaling pathway. The selective inhibition of ROCK by Y-27632 can disrupt the signaling pathways necessary for the proper functioning of RINZF, thereby inhibiting its activity. The p38 MAPK signaling pathway, which is involved in the stress response and can regulate transcription factors, is targeted by PD169316 and SB203580. These inhibitors can consequently reduce the transcriptional activity that RINZF influences by attenuating p38 MAPK activity. SP600125, by inhibiting JNK, can decrease the activation of transcription factors regulated by RINZF, thereby inhibiting its function.
Furthermore, PI3K signaling, which plays a crucial role in regulating transcription factors and is interconnected with multiple cellular signaling pathways, is a target of LY294002 and Wortmannin. By inhibiting PI3K, these inhibitors can lead to a reduction in the transcriptional activity within RINZF's regulatory scope. U0126 disrupts the MAPK pathway by inhibiting MEK1/2, leading to diminished ERK activation and subsequent inhibition of RINZF's regulatory functions. Triciribine inhibits AKT, a kinase involved in cell survival and transcription factor regulation, which can reduce the processes and transcriptional events involving RINZF. PP2, an inhibitor of Src family kinases, can decrease the activity of pathways that regulate transcription factors like RINZF. Bisindolylmaleimide I targets protein kinase C (PKC), which affects the regulation of transcription factors; by inhibiting PKC, this compound can reduce the activity of transcriptional regulators and thereby functionally inhibit RINZF. Lastly, Thapsigargin disrupts calcium homeostasis by inhibiting the SERCA pump; the resulting perturbation in cellular signaling can inhibit signaling pathways relevant to RINZF's activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
Alsterpaullone is known to inhibit cyclin-dependent kinases (CDKs). Since RINZF is involved in the regulation of transcription factors and CDKs play a crucial role in cell cycle regulation and transcription, inhibition of CDKs by Alsterpaullone can lead to a decrease in transcription factor availability, thus functionally inhibiting RINZF. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK (Rho-associated protein kinase). RINZF is implicated in transcriptional regulation that might be downstream of RhoA/ROCK signaling. Therefore, Y-27632 can inhibit ROCK, which in turn can inhibit the signaling pathways necessary for RINZF function. | ||||||
PD 169316 | 152121-53-4 | sc-204168 sc-204168A sc-204168B sc-204168C | 1 mg 5 mg 10 mg 25 mg | $86.00 $153.00 $275.00 $452.00 | 3 | |
PD169316 is a selective inhibitor of p38 MAPK. p38 MAPK is involved in stress response pathways and can regulate transcription factors. As RINZF is a transcription factor, inhibition of p38 MAPK by PD169316 can reduce the transcriptional activity influenced by RINZF. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK (c-Jun N-terminal kinase), which is involved in regulatory processes including transcription factor modulation. By inhibiting JNK, SP600125 can decrease the activation of transcription factors that RINZF may regulate, thereby inhibiting RINZF function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is known to inhibit p38 MAPK specifically. As RINZF is connected to transcriptional regulation which can be influenced by p38 MAPK activity, inhibition by SB203580 can lead to a reduction in RINZF's functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K signaling can regulate various transcription factors and is interconnected with multiple signaling pathways. Inhibition of PI3K by LY294002 can lead to a decrease in transcriptional activity that RINZF influences. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent inhibitor of PI3K. Similar to LY294002, by inhibiting PI3K, Wortmannin can indirectly inhibit the functionality of RINZF by reducing the transcriptional activity within its regulatory scope. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. As RINZF is a transcription factor potentially regulated by the MAPK pathway, inhibition of MEK by U0126 can diminish ERK activation, thereby inhibiting the function of RINZF. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an AKT inhibitor. The AKT pathway is involved in cell survival and transcription factor regulation. Inhibiting AKT with Triciribine can reduce the cellular processes and transcriptional events that RINZF is involved in, leading to its functional inhibition. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is an Src family kinase inhibitor. Src kinases can influence various cellular pathways including those regulating transcription factors like RINZF. Inhibition by PP2 can lead to decreased Src kinase activity, potentially inhibiting RINZF functionality. | ||||||