The chemical class known as Rhox6 Activators encompasses a diverse range of compounds that share the common ability to initiate a cellular cascade resulting in the activation of the Rhox6 protein. These activators work by targeting various signaling pathways and cellular mechanisms that ultimately contribute to changes in gene expression. One of the primary methods by which these activators function is by modulating the cellular concentration of second messengers such as cAMP. This modulation can activate key protein kinases that are crucial in the phosphorylation of specific transcription factors or other proteins that interact with the transcriptional machinery. By influencing these kinases, the activators can indirectly influence the transcriptional activity of genes, including those regulated by Rhox6.
In addition to affecting second messenger systems, certain activators in this class function by altering the epigenetic landscape of the cell. They achieve this by inhibiting enzymes responsible for DNA methylation or histone deacetylation, leading to changes in chromatin structure that facilitate transcription factor binding and gene expression. Others interact with cellular receptors and influence gene transcription via hormone-like signaling mechanisms. Some activators also impact cellular differentiation and proliferation pathways, which can have downstream effects on the expression of a multitude of genes, including transcription factors. The precise molecular pathways through which these activators exert their influence are complex and involve a multitude of intracellular interactions and feedback mechanisms. As a result, the activators within the Rhox6 Activators class are not only diverse in their structure but also in the mechanisms through which they modulate cellular processes to foster an environment conducive to Rhox6 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Influences gene transcription and is known to regulate homeobox genes during development, which could possibly activate Rhox6. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylyl cyclase, raising cAMP levels, which can lead to the activation of protein kinase A (PKA) and could possibly activate Rhox6 through transcription factor modulation. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can cause DNA demethylation, potentially leading to the activation of gene expression, which could possibly activate Rhox6. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
An inhibitor of histone deacetylases (HDACs) that can lead to a more open chromatin structure and could possibly activate Rhox6 by increasing gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol found in green tea that can modulate various signaling pathways and could possibly activate Rhox6 by influencing gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
An HDAC inhibitor that can lead to histone hyperacetylation, affecting gene transcription, which could possibly activate Rhox6. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC), which can lead to changes in transcription factor activity and could possibly activate Rhox6 by altering gene expression. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
A cAMP analog that can permeate cell membranes and mimic the action of cAMP, potentially affecting PKA and could possibly activate Rhox6 by influencing gene transcription. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
A hormone that can bind estrogen receptors and could possibly activate Rhox6 by influencing gene expression, including the regulation of transcription factors. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits glycogen synthase kinase 3 (GSK-3) and could possibly activate Rhox6 by affecting Wnt signaling and gene transcription. | ||||||