Rhox2b inhibitors are a class of chemical compounds that specifically target and inhibit the function of Rhox2b, a transcription factor that is part of the Rhox (Reproductive Homeobox) gene family. Rhox2b is involved in the regulation of gene expression, particularly in processes related to cellular development, differentiation, and reproductive biology. Like other Rhox family members, Rhox2b contains a conserved homeobox domain that allows it to bind to specific DNA sequences, thereby controlling the transcription of genes that are essential for cell growth and development. Inhibitors of Rhox2b typically function by binding to its DNA-binding domain or other regions crucial for its interaction with DNA and regulatory proteins, effectively blocking its ability to regulate target gene expression.
Inhibiting Rhox2b can lead to significant disruptions in the transcriptional programs it controls, particularly in tissues and cells where Rhox2b plays a key role. By preventing Rhox2b from binding to its target genes, these inhibitors alter cellular processes that rely on the precise control of gene expression, such as tissue development and differentiation. Researchers use Rhox2b inhibitors to gain deeper insights into the functional role of this transcription factor within gene regulatory networks. These inhibitors help dissect how Rhox2b influences cellular pathways and how it interacts with other proteins in complex biological systems. Additionally, Rhox2b inhibitors are valuable tools for studying the broader Rhox gene family, allowing scientists to explore the functional diversity and specialization of Rhox genes across different species. Through these inhibitors, researchers can investigate the molecular mechanisms by which transcription factors like Rhox2b contribute to the regulation of developmental and reproductive processes, shedding light on the evolutionary conservation and adaptation of gene regulation in various organisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent could be incorporated into the gene sequence of Rhox2b, potentially inhibiting its expression by disrupting normal DNA methylation patterns and altering gene regulation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic Acid may disrupt histone modification around the Rhox2b locus, which could lead to a more condensed chromatin state and lower gene expression levels. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium Butyrate's inhibition of histone deacetylases could cause chromatin remodeling that might reduce the expression of Rhox2b by making the DNA less accessible for transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid might impact Rhox2b expression by binding to retinoic acid receptors, which can regulate gene transcription, potentially inhibiting the activity of Rhox2b's promoter. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Through its hormonal action, Vitamin D3 may modulate transcription factor binding and affect the expression of various genes, including potentially Rhox2b. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
By binding to DNA, Mithramycin A could inhibit transcription factor binding to the Rhox2b promoter, potentially decreasing gene expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
As an mTOR inhibitor, Rapamycin could indirectly downregulate Rhox2b expression by altering the cellular signaling pathways involved in gene regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
The PI3K inhibitor LY294002 may decrease Rhox2b expression by disrupting PI3K-dependent signaling pathways that can regulate gene transcription. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $359.00 $1295.00 | 2 | |
Inhibiting the Wnt/β-catenin signaling pathway with Wnt-C59 could lead to changes in transcriptional programs, potentially affecting Rhox2b expression. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
DAPT inhibits gamma-secretase, an enzyme involved in the Notch signaling pathway, and could therefore influence Rhox2b expression by altering cellular differentiation signals. | ||||||