RhCE Inhibitors
RhCE Inhibitors refers to a collection of chemicals that can influence the RhCE protein, mainly through indirect modulation of pathways or cellular processes associated with its expression. The central theme among these compounds is their capability to impact erythropoiesis or other relevant biological processes in erythroid lineage cells, leading to alterations in the expression of surface proteins like RhCE.
A significant portion of these compounds, such as Hydroxyurea, and Thalidomide, influence the process of erythropoiesis directly. By altering red blood cell production or maturation, these agents can affect the final composition of proteins displayed on the red cell surface. Others, like Rapamycin and Imatinib, target broader cellular pathways like mTOR signaling and tyrosine kinases, respectively. These pathways intersect with erythroid development, thereby influencing proteins such as RhCE. A distinct set of compounds, Decitabine and 5-Azacytidine, affect DNA methylation, leading to changes in gene expression patterns that may encompass RhCE. Agents like Lenalidomide and Valproic acid exert effects on immune or inflammatory pathways and chromatin remodeling, respectively, again illustrating the diverse mechanisms by which RhCE expression can be indirectly modulated.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Influences erythropoiesis, which can indirectly affect the expression of proteins on red blood cells. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Modulates mTOR signaling, which has roles in cellular growth and could indirectly affect erythroid lineage cells. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Tyrosine kinase inhibitor which can influence erythroid development, potentially influencing RhCE expression. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $49.00 $367.00 $2030.00 | 18 | |
Can modulate immune and inflammatory pathways and influence erythropoiesis indirectly. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
A DNA methyltransferase inhibitor that can influence gene expression, potentially affecting RhCE indirectly. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
Similar to decitabine, this compound can affect DNA methylation and influence gene expression patterns. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $109.00 $350.00 | 8 | |
Known to modulate erythropoiesis, potentially influencing the expression of surface proteins like RhCE. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $53.00 | 10 | |
Affects bone marrow and erythropoiesis, thus can indirectly influence red cell protein expression. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Histone deacetylase inhibitor, influencing gene expression and could potentially affect RhCE expression. | ||||||
Busulfan | 55-98-1 | sc-204658 | 10 g | $48.00 | 3 | |
Alkylating agent that affects bone marrow, influencing erythropoiesis and potentially RhCE expression. | ||||||