Molecular structure of Busulfan, CAS Number: 55-98-1
Busulfan (CAS 55-98-1)
See product citations (3)
Application:
Busulfan is a DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins
CAS Number:
55-98-1
Purity:
≥98%
Molecular Weight:
246.3
Molecular Formula:
C6H14O6S2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Busulfan is an antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5′-GA-3′ and, to a lesser extent, at 5′-GG-3′ sequences. Forms an intrastrand cross-link at the 5′-GA-3′ sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.
Busulfan (CAS 55-98-1) References
- DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect. | Iwamoto, T., et al. 2004. Cancer Sci. 95: 454-8. PMID: 15132775
- Busulfan pharmacokinetics, toxicity, and low-dose conditioning for autologous transplantation of genetically modified hematopoietic stem cells in the rhesus macaque model. | Kang, EM., et al. 2006. Exp Hematol. 34: 132-9. PMID: 16459181
- Kinetic of genotoxic expression in the pharmacodynamics of busulfan. | Morales-Ramírez, P., et al. 2006. Arch Med Res. 37: 316-21. PMID: 16513478
- Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway. | Probin, V., et al. 2007. Free Radic Biol Med. 42: 1858-65. PMID: 17512465
- Physico-chemical stability of busulfan in injectable solutions in various administration packages. | Houot, M., et al. 2013. Drugs R D. 13: 87-94. PMID: 23549912
- Characterization and intramolecular bonding patterns of busulfan: Experimental and quantum chemical approach. | Karthick, T., et al. 2017. Spectrochim Acta A Mol Biomol Spectrosc. 173: 390-399. PMID: 27697721
- Evaluation of the Pharmacokinetics and Efficacy of a Busulfan Test Dose in Adult Patients Undergoing Myeloablative Hematopoietic Cell Transplantation. | Weil, E., et al. 2017. Biol Blood Marrow Transplant. 23: 952-957. PMID: 28288949
- Pharmacometabolomics for predicting variable busulfan exposure in paediatric haematopoietic stem cell transplantation patients. | Kim, B., et al. 2017. Sci Rep. 7: 1711. PMID: 28490733
- Stability of busulfan solutions in polypropylene syringes and infusion bags as determined with an original assay. | Guichard, N., et al. 2017. Am J Health Syst Pharm. 74: 1887-1894. PMID: 29118046
- Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning. | Solans, BP., et al. 2020. Br J Clin Pharmacol. 86: 1537-1549. PMID: 32077123
- Dispersive micro solid phase extraction of busulfan from plasma samples using novel mesoporous sorbent prior to determination by HPLC-MS/MS. | Jahed, FS., et al. 2020. J Chromatogr B Analyt Technol Biomed Life Sci. 1145: 122091. PMID: 32315975
- Stability-Indicating Method Development and Validation for Busulfan Drug Substance by Gas Chromatography-Flame Ionization Detector. | Khan, A., et al. 2021. J Chromatogr Sci. 59: 112-119. PMID: 33290539
- Fixed-dose administration and pharmacokinetically guided adjustment of busulfan dose for patients undergoing hematopoietic stem cell transplantation: a meta-analysis and cost-effectiveness analysis. | Chen, T., et al. 2022. Ann Hematol. 101: 667-679. PMID: 35091794
- Toxicological review of busulfan (Myleran). | Bishop, JB. and Wassom, JS. 1986. Mutat Res. 168: 15-45. PMID: 3713721
- Busulfan disposition: the role of therapeutic monitoring in bone marrow transplantation induction regimens. | Grochow, LB. 1993. Semin Oncol. 20: 18-25; quiz 26. PMID: 8342071
Inhibitor of:
4732415M23Rik, 4930458L03Rik, 4930542N07Rik, 4931408C20Rik, 4932411G14Rik, 4933413G19Rik, AChRα, ALAS-E, BOULE, C6orf10, CTAGE3, FIGLA, gametogenetin, Gm597, MEA-1, rat thymocytes, bone marrow, RhCE, SPATA16, SPATA25, SPATA9, SPEER-2, SPNR, TEX19, and TPO.Activator of:
Ada.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Busulfan, 10 g | sc-204658 | 10 g | $49.00 |