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Busulfan (CAS 55-98-1) - chemical structure image
Molecular structure of Busulfan, CAS Number: 55-98-1
Busulfan (CAS 55-98-1) - chemical structure image
Molecular structure of Busulfan, CAS Number: 55-98-1
Molecular structure of Busulfan, CAS Number: 55-98-1

Busulfan (CAS 55-98-1)

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See product citations (3)

Application:
Busulfan is a DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins
CAS Number:
55-98-1
Purity:
≥98%
Molecular Weight:
246.3
Molecular Formula:
C6H14O6S2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Description
Technical Information
Safety Information
SDS & Certificate of Analysis

Busulfan is an antineoplastic bifunctional, DNA alkylating agent that causes DNA damage by cross-linking DNA and proteins. Causes double-base lesions mainly at 5′-GA-3′ and, to a lesser extent, at 5′-GG-3′ sequences. Forms an intrastrand cross-link at the 5′-GA-3′ sequence, and to monoalkylation. Induces normal human fibroblast senescence selectively through Erk and p38 pathways.


Busulfan (CAS 55-98-1) References

  1. DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect.  |  Iwamoto, T., et al. 2004. Cancer Sci. 95: 454-8. PMID: 15132775
  2. Busulfan pharmacokinetics, toxicity, and low-dose conditioning for autologous transplantation of genetically modified hematopoietic stem cells in the rhesus macaque model.  |  Kang, EM., et al. 2006. Exp Hematol. 34: 132-9. PMID: 16459181
  3. Kinetic of genotoxic expression in the pharmacodynamics of busulfan.  |  Morales-Ramírez, P., et al. 2006. Arch Med Res. 37: 316-21. PMID: 16513478
  4. Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway.  |  Probin, V., et al. 2007. Free Radic Biol Med. 42: 1858-65. PMID: 17512465
  5. Physico-chemical stability of busulfan in injectable solutions in various administration packages.  |  Houot, M., et al. 2013. Drugs R D. 13: 87-94. PMID: 23549912
  6. Characterization and intramolecular bonding patterns of busulfan: Experimental and quantum chemical approach.  |  Karthick, T., et al. 2017. Spectrochim Acta A Mol Biomol Spectrosc. 173: 390-399. PMID: 27697721
  7. Evaluation of the Pharmacokinetics and Efficacy of a Busulfan Test Dose in Adult Patients Undergoing Myeloablative Hematopoietic Cell Transplantation.  |  Weil, E., et al. 2017. Biol Blood Marrow Transplant. 23: 952-957. PMID: 28288949
  8. Pharmacometabolomics for predicting variable busulfan exposure in paediatric haematopoietic stem cell transplantation patients.  |  Kim, B., et al. 2017. Sci Rep. 7: 1711. PMID: 28490733
  9. Stability of busulfan solutions in polypropylene syringes and infusion bags as determined with an original assay.  |  Guichard, N., et al. 2017. Am J Health Syst Pharm. 74: 1887-1894. PMID: 29118046
  10. Modelling of neutrophil dynamics in children receiving busulfan or treosulfan for haematopoietic stem cell transplant conditioning.  |  Solans, BP., et al. 2020. Br J Clin Pharmacol. 86: 1537-1549. PMID: 32077123
  11. Dispersive micro solid phase extraction of busulfan from plasma samples using novel mesoporous sorbent prior to determination by HPLC-MS/MS.  |  Jahed, FS., et al. 2020. J Chromatogr B Analyt Technol Biomed Life Sci. 1145: 122091. PMID: 32315975
  12. Stability-Indicating Method Development and Validation for Busulfan Drug Substance by Gas Chromatography-Flame Ionization Detector.  |  Khan, A., et al. 2021. J Chromatogr Sci. 59: 112-119. PMID: 33290539
  13. Fixed-dose administration and pharmacokinetically guided adjustment of busulfan dose for patients undergoing hematopoietic stem cell transplantation: a meta-analysis and cost-effectiveness analysis.  |  Chen, T., et al. 2022. Ann Hematol. 101: 667-679. PMID: 35091794
  14. Toxicological review of busulfan (Myleran).  |  Bishop, JB. and Wassom, JS. 1986. Mutat Res. 168: 15-45. PMID: 3713721
  15. Busulfan disposition: the role of therapeutic monitoring in bone marrow transplantation induction regimens.  |  Grochow, LB. 1993. Semin Oncol. 20: 18-25; quiz 26. PMID: 8342071

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Busulfan, 10 g

sc-204658
10 g
$49.00

Hi there, Could I please get an example COA from your most recent lot? My company is considering using this material as a CRS and needs to know if any additional testing would be required before it is suitable for GMP use.

Asked by: apfc
Thank you for your question. Each lot of this chemical comes with a lot-specific Certificate of Analysis which typically describes the percent purity as well as the method used to determine the purity. You may request a lot-specific Certificate of Analysis on our website. Alternatively, please contact our Technical Service Department or reach out to your local distributor to inquire about the purity of our most recent lot.
Answered by: Technical Service
Date published: 2022-02-09

Hi, can you please send us a price offer for busulfan? We are from the Institute of Cellular Biology and Pathology "N Simionescu", Bucharest, Romania. Thank you. Regards, Ana Vacaru, PhD

Asked by: AnaV
Thank you for your message. Our Customer Service department will contact you asap with the lead time and price quotation for this product. Most of our products are currently on stock in our European Support Office and we ship these over night, however specific delivery time can depend by destination, amount and current availability.
Answered by: Technical Support Europe
Date published: 2018-07-03

What is the storage once the compound is in solution in DMSO?

Asked by: two2igm05
Thank you for your question. This product has standard long term storage, aliquot into single size uses (avoid freeze/thaw cycles) at -80℃, will last at least 6 months. You can also store in -20°C in single aliquots for a shorter period of time.
Answered by: Technical Support
Date published: 2017-01-11

How should Busulfan be stored once it has been solubilized in DMSO?

Asked by: ChemSynth123
Thank you for your question. It is recommended to use solutions the same day they are made. A DMSO solution containing sc-204658 should be aliquoted into single size uses and stored at -80℃. The aliquots should be stable for at least 6 months when stored at -80ºC. The aliquots can be stored at -20°C for a shorter period of time. Multiple freeze/thaw cycles should be avoided.
Answered by: Technical Support
Date published: 2016-12-14
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Rated 5 out of 5 by from JungJung, SW. et al. (PubMed 26199556) used the DNA alkylating agent Busulfan to induce dysfunction of the male reproductive system. -SCBT Publication Review
Date published: 2015-04-20
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Busulfan is rated 5.0 out of 5 by 1.
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