REXO2 Inhibitors
The chemical group referred to as REXO2 Inhibitors encompasses a broad spectrum of compounds whose central theme revolves around the modulation of nucleic acid metabolism. These compounds have diverse origins and mechanisms, yet they converge upon pathways that either directly or indirectly influence the activity of ribonucleases such as REXO2.
Compounds like Hydroxyurea, 5-Azacytidine, Cytarabine, and Decitabine serve as exemplars, shedding light on the myriad ways by which nucleotide pools and synthesis can be modulated. Hydroxyurea, for instance, takes on the crucial enzyme ribonucleotide reductase, steering the tide of nucleotide availability and thereby affecting the role of REXO2. Nucleoside analogs, represented here by 5-Azacytidine, Cytarabine, and Decitabine, underscore another layer of complexity. Their incorporation into the nucleic acid chains can disrupt the natural progression of DNA and RNA synthesis. Compounds like α-Amanitin, DRB, and Leptomycin B elucidate another dimension of RNA metabolism, targeting RNA polymerase II or the very infrastructure of nucleic acid transport and export.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, potentially causing an imbalance in nucleotide pools which could affect the substrates or activity of REXO2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a nucleoside analog, upon incorporation into RNA, it may alter the substrates REXO2 interacts with, possibly affecting its ribonuclease activity. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
1-β-D-Arabinofuranosylcytosine, when incorporated, hinders DNA synthesis. This alteration in DNA metabolism could indirectly influence the activity or availability of REXO2 targets. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
By affecting DNA methylation and nucleic acid metabolism, Decitabine could change the substrate landscape for REXO2. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
By inhibiting RNA polymerase II, α-Amanitin reduces RNA synthesis, potentially affecting the amount or type of RNA substrates available for REXO2. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D binds to DNA, obstructing RNA synthesis. This could modify the RNA pool that REXO2 interacts with. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB inhibits RNA polymerase II, impacting RNA metabolism, and potentially modifying the RNA substrates REXO2 acts upon. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
By inhibiting nuclear export, Leptomycin B could affect the cellular location and availability of REXO2's RNA substrates. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $69.00 $266.00 | 8 | |
Affecting purine synthesis by inhibiting inosine monophosphate dehydrogenase, Mycophenolic acid might indirectly alter the RNA or DNA substrates for REXO2. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $63.00 $110.00 $214.00 | 1 | |
Ribavirin interferes with RNA metabolism and synthesis, potentially changing the quality or quantity of RNA available for REXO2's action. | ||||||