Rev-erbβ Activators
The first class of Rev-erbβ activators are those that alter kinase activity, such as lithium, rapamycin, quercetin, and LY294002. These compounds target kinases like GSK3β, mTOR, and PI3K, which have direct or indirect interactions with Rev-erbβ. Inhibition of these kinases can result in the enhancement of Rev-erbβ function. For instance, lithium inhibits GSK3β, a kinase that phosphorylates Rev-erbβ, thereby indirectly enhancing its functional activity.
The second class of Rev-erbβ activators are those that modulate cellular stress response and energy sensing pathways, such as resveratrol, forskolin, metformin, sulforaphane, SRT1720, AICAR, berberine, and N-acetylcysteine. These compounds can activate cellular pathways like Sirt1, AMPK, and Nrf2, or increase cAMP levels, which are known to affect the function of Rev-erbβ. For instance, resveratrol activates Sirt1, which deacetylates and activates Rev-erbβ, thus enhancing its function. Similarly, metformin and AICAR, as AMPK activators, can enhance the functional activity of Rev-erbβ, as AMPK activation has been linked to an increase in its functional activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium is known to inhibit GSK3β, a kinase that phosphorylates Rev-erbβ. By inhibiting GSK3β, lithium can indirectly enhance the functional activity of Rev-erbβ, leading to an increase in its downstream effects. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor, which indirectly activates Rev-erbβ via autophagy. mTOR inhibits autophagy, and autophagy activation is linked with the activation of Rev-erbβ. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates Sirt1, which has been shown to deacetylate and activate Rev-erbβ. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels. Elevated cAMP can enhance the function of Rev-erbβ by promoting its nuclear localization. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMPK. AMPK activation has been linked to an increase in the functional activity of Rev-erbβ. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2, which can indirectly influence Rev-erbβ by modulating oxidative stress, which is known to affect the function of Rev-erbβ. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin inhibits PI3K, a kinase that negatively regulates Rev-erbβ. PI3K inhibition can indirectly enhance the functional activity of Rev-erbβ. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
SRT1720 is a specific activator of Sirt1. Sirt1 activation enhances the function of Rev-erbβ by deacetylating it, leading to its activation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMPK activator. AMPK activation enhances the functional activity of Rev-erbβ. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $92.00 | 1 | |
Berberine activates AMPK. Activation of AMPK has been linked to an increase in the functional activity of Rev-erbβ. | ||||||