REG3α Activators
Regenerating islet-derived protein 3-alpha (REG3α) is an intriguing protein in the context of biological research due to its involvement in the innate immune system and its expression in the gastrointestinal tract. As a C-type lectin, REG3α serves a crucial role in the body's first line of defense, particularly by exhibiting bactericidal properties against Gram-positive bacteria. This protein is not only pivotal in immune defense but also in the maintenance and repair of the intestinal mucosa. The ability of REG3α to stimulate epithelial cell proliferation underscores its importance in tissue regeneration and homeostasis. Given its significant role in these fundamental biological processes, understanding the regulation of REG3α not only contributes to our knowledge of gut physiology but also extends to insights into the complex interactions between host and microbiota.
The expression of REG3α can be influenced by a variety of chemical compounds, which are often naturally occurring within the body or found in dietary sources. Short-chain fatty acids like butyrate, produced through the fermentation of dietary fibers by gut microbes, are known to stimulate the production of REG3α, reflecting the intimate cross-talk between diet, microbiota, and mucosal immunity. Similarly, bioactive dietary components such as curcumin, resveratrol, and sulforaphane, commonly found in turmeric, grapes, and cruciferous vegetables respectively, have been associated with increased REG3α expression. These compounds, along with secondary bile acids like lithocholic acid and deoxycholic acid, which are products of hepatic metabolism and microbial transformation, play a role in maintaining mucosal barrier integrity by stimulating the production of REG3α. Moreover, vitamins and their metabolites, such as retinoic acid from vitamin A and 1,25-dihydroxyvitamin D3, the active form of vitamin D, also contribute to the regulation of REG3α expression, highlighting the intricate interplay between nutrition and immune defense mechanisms. The upregulation of this protein by such a diverse array of compounds reflects the body's adaptive mechanisms to maintain gastrointestinal health and protect against microbial imbalances.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, found in vitamin A, promotes the differentiation of immune cells in the gut and can directly stimulate the upsurge in REG3α production. It plays a central role in gut immunity and can prompt epithelial cells to increase REG3α synthesis to reinforce the mucosal barrier against pathogens. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
This hormonally active form of vitamin D is crucial for calcium homeostasis and bone metabolism, and it also stimulates the expression of REG3α in the gastrointestinal tract. It enhances innate immunity by promoting the expression of antimicrobial peptides, including REG3α, contributing to the protection of the mucosal surface. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $100.00 $272.00 | 1 | |
Lithocholic acid, a byproduct of bile acid metabolism by gut microbiota, can increase REG3α expression. This secondary bile acid has been shown to stimulate the production of antimicrobial peptides, including REG3α, as a protective response against bacterial overgrowth and infection. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a bioactive compound of turmeric, has been shown to stimulate the expression of REG3α. Its anti-inflammatory properties are linked to the enhancement of intestinal barrier function, in part by upregulating the expression of antimicrobial peptides like REG3α. | ||||||
Deoxycholic acid | 83-44-3 | sc-214865 sc-214865A sc-214865B | 5 g 25 g 1 kg | $37.00 $67.00 $941.00 | 4 | |
Deoxycholic acid, another secondary bile acid formed in the colon, can stimulate the secretory response of antimicrobial peptides, including REG3α. Its role in the enterohepatic circulation includes signaling functions that trigger the production of defensive molecules in the gut lining. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, the spicy compound in hot peppers, may stimulate the production of REG3α. This bioactive molecule triggers a defense response in the gut that includes the upregulation of REG3α, contributing to protection against microbial intrusion. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Ursolic acid, a natural pentacyclic triterpenoid, can increase the expression of REG3α. It's known for its role in promoting wound healing and anti-inflammatory responses, part of which involves stimulating the release of REG3α to bolster mucosal defense. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane, a compound within the isothiocyanate group of organosulfur compounds, can induce the expression of REG3α. It is found in high amounts in broccoli and other cruciferous vegetables and may activate signaling pathways that lead to the production of antimicrobial peptides. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid, present in pomegranates, berries, and nuts, has been associated with the upregulation of REG3α expression. It may play a role in protecting the gut lining from oxidative stress and microbial challenge by stimulating the release of antimicrobial peptides. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a stilbenoid found in grapes and berries, can stimulate the production of REG3α. As an antioxidant, it may enhance the gut's defense mechanisms, including the upregulation of antimicrobial peptides, to maintain a balanced microbial environment. | ||||||