RECS1 Inhibitors
Chemical inhibitors of RECS1 can disrupt its function through various mechanisms that impinge on the endoplasmic reticulum (ER) stress response pathways. Brefeldin A, for instance, inhibits the ADP-ribosylation factor, leading to a disruption of vesicle trafficking, which can cause mislocalization and accumulation of misfolded proteins in the ER, thereby impairing the function of RECS1. Similarly, Tunicamycin interferes with N-linked glycosylation, a process critical for the proper folding and function of many proteins, including RECS1. This disruption can lead to a loss of RECS1 function due to the accumulation of improperly folded proteins. Thapsigargin and Cyclopiazonic Acid both inhibit the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to a depletion of calcium stores within the ER. This depletion can cause a dysregulation of calcium homeostasis, a condition that RECS1 is implicated in managing, and the resulting ER stress can inhibit the regulatory functions of RECS1.
Further, Betulinic Acid induces ER stress and disrupts mitochondrial function, which can overload RECS1's capacity to manage these stress responses. Chemicals like Salubrinal, Guanabenz, and Sephin1 inhibit the dephosphorylation of eIF2α, a critical factor in the ER stress response. The heightened stress response resulting from these inhibitors can overwhelm the regulatory mechanisms in which RECS1 is involved, inhibiting its function. Eeyarestatin I disrupts the ER-associated degradation pathway, leading to an accumulation of misfolded proteins in the ER, which can exacerbate the stress condition and inhibit the function of RECS1. 4-Phenylbutyrate, while acting as a chemical chaperone to reduce ER stress, can also alter the stress signaling environment and thus affect the function of RECS1. Lastly, MG132 inhibits the proteasome, which leads to the accumulation of polyubiquitinated proteins and subsequent induction of ER stress. This accumulation can disturb ER homeostasis and inhibit the function of RECS1 due to the increased load of proteins awaiting degradation. Nelfinavir induces ER stress and the unfolded protein response, which, in turn, can inhibit RECS1 by initiating a stress response that RECS1 might not be able to manage effectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Brefeldin A inhibits ADP-ribosylation factor (ARF), a small GTPase involved in vesicle trafficking. RECS1 is implicated in endoplasmic reticulum stress responses, and inhibition of ARF by Brefeldin A can disrupt protein trafficking and secretion, potentially leading to functional inhibition of RECS1 by causing mislocalization and accumulation of misfolded proteins. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin blocks N-linked glycosylation by inhibiting the first step in the synthesis of the lipid-linked oligosaccharides that are necessary for N-glycan production. As protein glycosylation can be crucial for the folding and function of some membrane proteins, the inhibition of this process can impair the proper function and stability of RECS1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a potent inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), disrupting calcium homeostasis. Since RECS1 is a part of the endoplasmic reticulum stress response, perturbation of calcium levels can inhibit the regulatory capacity of RECS1 by inducing stress responses that RECS1 cannot mitigate, leading to its functional inhibition. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic Acid is another inhibitor of SERCA, leading to depletion of ER calcium stores. Similar to Thapsigargin, by altering calcium homeostasis, Cyclopiazonic Acid can disrupt the proper functioning of RECS1 through induction of ER stress. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $115.00 $337.00 | 3 | |
Betulinic Acid induces endoplasmic reticulum stress and can cause mitochondrial dysfunction. By inducing ER stress, Betulinic Acid can overload the functional capacity of RECS1, which is involved in responding to such stress, leading to inhibition of its proper function. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal selectively inhibits phosphatases that dephosphorylate eIF2α, thereby enhancing eIF2α phosphorylation and attenuating translation. Since RECS1 is involved in ER stress response, the heightened stress response due to Salubrinal can functionally inhibit RECS1 by overwhelming its regulatory mechanisms. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
Eeyarestatin I inhibits the p97 ATPase and ER-associated degradation (ERAD) pathway, which can lead to accumulation of misfolded proteins in the ER. This can inhibit the function of RECS1 by exacerbating ER stress and disrupting the cellular environment RECS1 operates within. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $100.00 $459.00 $816.00 $4080.00 $7140.00 | 2 | |
Guanabenz selectively inhibits the dephosphorylation of eIF2α, which can lead to an exaggerated stress response. By increasing phosphorylation of eIF2α, Guanabenz can indirectly inhibit RECS1 by enhancing ER stress beyond the protein's regulatory capabilities. | ||||||
Sephin1 | 13098-73-2 | sc-507502 | 5 mg | $578.00 | ||
Sephin1 also selectively inhibits the dephosphorylation of eIF2α, similar to Guanabenz and Salubrinal, it can disrupt the function of RECS1 by inducing a heightened stress response that exceeds RECS1's regulatory function. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
4-Phenylbutyrate acts as a chemical chaperone that can reduce ER stress. However, by affecting the ER stress pathway, it can indirectly inhibit RECS1 by altering the stress signaling milieu in which RECS1 operates, potentially reducing the need for RECS1's function. | ||||||