RDH14 Inhibitors
RDH14 inhibitors, such as, Citral and Disulfiram can reduce the availability of retinoid substrates or alter their metabolism, which can in turn affect the catalytic role of RDH14. Isotretinoin and Tretinoin, being retinoic acid analogs, can modulate the feedback mechanisms that control retinoid synthesis and degradation. This modulation can alter the balance of retinoid intermediates and end products, indirectly influencing RDH14's function. Flufenamic acid and Genistein have the capacity to interfere with retinoid signaling, which is intricately linked to the enzyme's activity.
Compounds such as Ketoconazole and Omeprazole, known to inhibit cytochrome P450 enzymes, can disrupt the broader retinoid metabolism network, thereby influencing RDH14 activity. Bisphenol A and Nitrofen, by disrupting endocrine function and retinoid signaling respectively, can lead to an indirect reduction in RDH14 activity. Lastly, Methotrexate and Aminoglutethimide, which affect dihydrofolate reductase and steroidogenesis, can also influence retinoid synthesis and metabolism, potentially altering the activity of RDH14.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
Interferes with retinoid synthesis; can limit the substrate availability for RDH14. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Alters aldehyde dehydrogenase activity; can modify the retinaldehyde levels, indirectly affecting RDH14 activity. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $74.00 $118.00 | 8 | |
A retinoic acid analog that can regulate retinoid metabolism, potentially diminishing RDH14's role. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Another retinoic acid analog that alters retinoid signaling; can indirectly affect RDH14 activity by changing retinoid homeostasis. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $26.00 $77.00 $151.00 $303.00 | 1 | |
Can affect retinoid signaling, possibly altering RDH14 activity. | ||||||
Ketoconazole | 65277-42-1 | sc-200496 sc-200496A | 50 mg 500 mg | $62.00 $260.00 | 21 | |
Inhibits cytochrome P450 enzymes; can disrupt retinoid metabolism and thus RDH14 function. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Known to disrupt endocrine function; can interfere with retinoid pathways, potentially affecting RDH14. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $66.00 | 4 | |
Proton pump inhibitor that can affect cytochrome P450 enzymes; may alter RDH14 activity indirectly. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A phytoestrogen that can modulate various signaling pathways, including those involving retinoids, affecting RDH14's activity. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
A dihydrofolate reductase inhibitor that can affect retinoid metabolism, potentially altering RDH14 activity. | ||||||