RDH12 Inhibitors
RDH12 inhibitors are compounds that directly or indirectly modulate the activity of the RDH12 enzyme, which plays a role in the conversion of all-trans-retinol to all-trans-retinal. Several of the compounds listed above act indirectly, primarily by affecting the broader retinoid metabolism. For instance, Citral and Disulfiram are known to inhibit certain aspects of retinol metabolism. By doing so, they can indirectly influence the activity of RDH12, either by altering the availability of its substrate or its product. Similarly, synthetic retinoids like Fenretinide, Acitretin, and Isotretinoin, can modulate the retinoid pathway. Their action on the retinoid metabolism can indirectly influence RDH12 by affecting the equilibrium between its substrate and product.
Moreover, compounds such as A1120 act on associated molecules, like the retinol binding protein, which transports retinol. By inhibiting this protein, the availability of retinol, and consequently the substrate for RDH12, can be affected.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Citral | 5392-40-5 | sc-252620 | 1 kg | $212.00 | ||
An aldehyde that can inhibit retinol metabolism. By altering the retinoid pool, it indirectly influences the activity of enzymes like RDH12. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Known for aldehyde dehydrogenase inhibition. By affecting the retinoid pathway, it can indirectly modulate RDH12 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
End product of retinol metabolism. Feedback mechanisms can decrease retinol availability, affecting RDH12 substrate levels. | ||||||
4-Hydroxyphenylretinamide | 65646-68-6 | sc-200900 sc-200900A | 5 mg 25 mg | $104.00 $315.00 | ||
Synthetic retinoid with multiple effects on the retinoid pathway. It can alter retinoid metabolism, potentially influencing RDH12 indirectly. | ||||||
Acitretin | 55079-83-9 | sc-210754 | 25 mg | $148.00 | 1 | |
Another synthetic retinoid. By modulating the retinoid pathway, RDH12 function can be influenced due to changes in substrate or product levels. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $74.00 $118.00 | 8 | |
A retinoid that alters the overall retinoid metabolism. Changes in the retinoid pool can modulate RDH12 activity. | ||||||
LE 135 | 155877-83-1 | sc-204053 sc-204053A | 10 mg 50 mg | $168.00 $707.00 | 5 | |
A retinoid receptor antagonist. By modulating retinoid signaling, it might influence the broader retinoid metabolism and thus RDH12. | ||||||
A 1120 | 1152782-19-8 | sc-361093 sc-361093A sc-361093B | 5 mg 25 mg 4 g | $125.00 $480.00 $16000.00 | ||
Direct inhibitor of retinol binding protein, affecting retinol transportation and availability, thus potentially influencing RDH12. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Broad-spectrum enzyme inhibitor. While not specific, suramin's impact on various pathways can indirectly affect RDH12's activity. | ||||||