Date published: 2026-5-18

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LE 135 (CAS 155877-83-1)

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Alternate Names:
LE-135
Application:
LE 135 is a retinoic acid receptor antagonist
CAS Number:
155877-83-1
Purity:
≥97%
Molecular Weight:
438.57
Molecular Formula:
C29H30N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.

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LE 135 is a retinoic acid receptor antagonist which displays moderate selectivity for RARbeta over RARalpha Additionally, LE 135 is highly selective over RARgamma and RXRalpha This compound also Inhibits human HL-60 leukemia cell differentiation induced by the retinoid Am80.


LE 135 (CAS 155877-83-1) References

  1. Identification of a novel class of retinoic acid receptor beta-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells.  |  Li, Y., et al. 1999. J Biol Chem. 274: 15360-6. PMID: 10336422
  2. Visible light exposure induces VEGF gene expression through activation of retinoic acid receptor-alpha in retinoblastoma Y79 cells.  |  Akiyama, H., et al. 2005. Am J Physiol Cell Physiol. 288: C913-20. PMID: 15613498
  3. Anti-hyperglycemic effect of Opuntia streptacantha Lem.  |  Andrade-Cetto, A. and Wiedenfeld, H. 2011. J Ethnopharmacol. 133: 940-3. PMID: 21111796
  4. Intracrine prostaglandin E(2) signalling regulates hypoxia-inducible factor-1α expression through retinoic acid receptor-β.  |  Fernández-Martínez, AB., et al. 2012. Int J Biochem Cell Biol. 44: 2185-93. PMID: 22964004
  5. Retinoic acid regulation by CYP26 in vertebrate lens regeneration.  |  Thomas, AG. and Henry, JJ. 2014. Dev Biol. 386: 291-301. PMID: 24384390
  6. All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function.  |  Bhatt, S., et al. 2014. J Immunol. 192: 5098-108. PMID: 24790153
  7. All-trans-retinoic Acid Increases SLC26A3 DRA (Down-regulated in Adenoma) Expression in Intestinal Epithelial Cells via HNF-1β.  |  Priyamvada, S., et al. 2015. J Biol Chem. 290: 15066-77. PMID: 25887398
  8. The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia.  |  Kurtys, E., et al. 2016. Neurochem Int. 99: 206-214. PMID: 27465516
  9. All-trans retinoic acid and human salivary histatin-1 promote the spreading and osteogenic activities of pre-osteoblasts in vitro.  |  Sun, W., et al. 2020. FEBS Open Bio. 10: 396-406. PMID: 31957262
  10. The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation.  |  Wang, S., et al. 2020. Drug Des Devel Ther. 14: 297-308. PMID: 32158187
  11. Retinoic acid receptor-beta prevents cisplatin-induced proximal tubular cell death.  |  Yago-Ibáñez, J., et al. 2020. Biochim Biophys Acta Mol Basis Dis. 1866: 165795. PMID: 32278009
  12. Differential expression of retinoic acid alpha and beta receptors in neuronal progenitors generated from human embryonic stem cells in response to TTNPB (a retinoic acid mimetic).  |  Das, M. and Pethe, P. 2021. Differentiation. 121: 13-24. PMID: 34419635
  13. Possible involvement of retinoid-like cofactor in serum in hemin/protoporphyrin-IX-induced differentiation of human leukemia K562 cells.  |  Nakajima, O., et al. 1995. Biochem Biophys Res Commun. 206: 1003-10. PMID: 7832789
  14. Retinobenzoic acids. 6. Retinoid antagonists with a heterocyclic ring.  |  Eyrolles, L., et al. 1994. J Med Chem. 37: 1508-17. PMID: 8182710
  15. Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.  |  Umemiya, H., et al. 1997. J Med Chem. 40: 4222-34. PMID: 9435893

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

LE 135, 10 mg

sc-204053
10 mg
$168.00
US: Only available in the US

LE 135, 50 mg

sc-204053A
50 mg
$707.00
US: Only available in the US