RBMX Inhibitors
The assortment of molecules classified as RBMX inhibitors function by modulating various intracellular pathways that indirectly influence the activity and expression of RBMX.Many of these inhibitors target key kinases involved in cellular signaling pathways that have been linked to the function of RBMX. For instance, inhibitors like PD98059 and U0126 target MEK, a component of the ERK/MAPK pathway. These inhibitors dampen the activity of the ERK/MAPK pathway, which is known to regulate the assembly of stress granules, a process in which RBMX is actively involved. Thus, by inhibiting this pathway, these chemicals can indirectly modulate the function of RBMX. On the other hand, PI3K inhibitors such as LY294002 and Wortmannin, along with the mTOR inhibitor Rapamycin, interrupt the PI3K/AKT pathway. Given RBMX's involvement in this pathway's related processes like cell survival and proliferation, inhibiting the PI3K/AKT pathway can indirectly modulate RBMX function.
Other chemicals in this class operate by modulating cellular processes that are not directly linked to a specific signaling pathway but are crucial for RBMX function. For example, BAPTA-AM, a calcium chelator, reduces intracellular calcium levels, indirectly influencing RBMX function, known to be involved in calcium-mediated cellular processes. Finally, inhibitors that act on protein or RNA synthesis, such as Cycloheximide and Actinomycin D, can also indirectly affect RBMX. By inhibiting the synthesis of new proteins or the transcription of RNA, these inhibitors can modulate the availability and function of RBMX within the cell. Similarly, broad-spectrum protein kinase inhibitors, such as Staurosporine, or specific inhibitors of PKC, like Bisindolylmaleimide I, can indirectly modulate RBMX function by affecting several kinase-regulated processes.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, a component of the ERK/MAPK pathway. By inhibiting MEK, PD98059 dampens the ERK/MAPK pathway. As RBMX is known to be involved in stress granule assembly, which is regulated by the ERK/MAPK pathway, the inhibition of this pathway by PD98059 indirectly affects the function of RBMX. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK. It prevents the phosphorylation and activation of p38 MAPK, thereby inhibiting the p38 MAPK pathway. RBMX can be modulated by the p38 MAPK pathway during cellular stress responses, so the inhibition of this pathway by SB203580 indirectly modulates RBMX function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a selective inhibitor of JNK. By inhibiting JNK activity, SP600125 dampens the JNK/MAPK pathway. RBMX is involved in RNA splicing, a process that can be influenced by the JNK/MAPK pathway, so inhibition of this pathway by SP600125 can indirectly affect RBMX function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. It prevents the phosphorylation and activation of AKT, a downstream target of PI3K, thereby inhibiting the PI3K/AKT pathway. As RBMX has been implicated in PI3K/AKT pathway-related processes such as cell survival and proliferation, the inhibition of this pathway by LY294002 can indirectly affect RBMX function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another PI3K inhibitor. Similar to LY294002, it inhibits the PI3K/AKT pathway. Given the involvement of RBMX in PI3K/AKT pathway-related processes, the inhibition of this pathway by Wortmannin can indirectly modulate RBMX function. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $449.00 | 61 | |
BAPTA-AM is a calcium chelator. It decreases intracellular calcium levels, thereby affecting various calcium-dependent signaling pathways. As RBMX has been implicated in calcium-mediated cellular processes, the reduction in intracellular calcium by BAPTA-AM can indirectly influence RBMX function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor. It inhibits mTOR, a key regulator of the PI3K/AKT pathway, thereby inhibiting this pathway. As RBMX has been implicated in PI3K/AKT pathway-related processes, the inhibition of this pathway by Rapamycin can indirectly modulate RBMX function. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is an inhibitor of protein synthesis. It binds to the 60S ribosomal subunit, preventing the elongation phase of protein synthesis. As RBMX is a protein involved in RNA splicing, the inhibition of protein synthesis by Cycloheximide can indirectly affect RBMX function. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D is an inhibitor of RNA synthesis. It binds to DNA, preventing RNA polymerase from carrying out transcription. As RBMX is involved in RNA splicing, the inhibition of RNA synthesis by Actinomycin D can indirectly affect RBMX function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. It inhibits various protein kinases, thereby affecting multiple signaling pathways. Given that RBMX is involved in several kinase-regulated processes, the inhibition of protein kinase activity by Staurosporine can indirectly modulate RBMX function. | ||||||