RBMX Activators
The collection of chemical compounds collectively referred to as RBMX activators represents a diverse array of molecules that can influence the function and activity of RBMX, either directly or indirectly. These compounds exert their effects by modulating various intracellular pathways and processes that are crucial for RBMX function. For example, Anisomycin, a JNK activator, stimulates the JNK/MAPK pathway which is known to influence RNA splicing, a process in which RBMX is actively involved. As such, activation of this pathway by Anisomycin can lead to increased RBMX activity. Forskolin, a stimulator of adenylyl cyclase, increases intracellular cAMP levels leading to PKA activation. PKA is known to influence RNA splicing, thereby indirectly modulating RBMX function. Other compounds in this collection work by increasing the phosphorylation levels of proteins. For instance, Calyculin A, Okadaic Acid, and Vanadate, all phosphatase inhibitors, lead to increased protein phosphorylation levels.
Also included in this collection are the chemicals Ionomycin, Thapsigargin, and Bradykinin, all of which increase intracellular calcium levels. Given that RBMX is implicated in calcium-mediated cellular processes, these chemicals can indirectly modulate its function. Bay 11-7082, while primarily an inhibitor of NF-κB activation, induces the phosphorylation and activation of ERK, a component of the ERK/MAPK pathway. RBMX is involved in stress granule assembly, a process regulated by the ERK/MAPK pathway. Hydrogen Peroxide, a reactive oxygen species, can also activate the ERK/MAPK pathway and thus indirectly influence RBMX function. The diverse array of compounds that can influence the function and activity of RBMX underscore the complexity of the cellular processes and pathways it is involved in. While these compounds do not directly activate RBMX, they can modulate its activity by affecting the pathways and processes in which it is involved.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator. It stimulates the JNK/MAPK pathway, which can indirectly modulate RBMX function as RBMX is implicated in RNA splicing, a process influenced by the JNK/MAPK pathway. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which increases intracellular levels of cAMP. This can lead to activation of PKA, which can modulate RBMX function as PKA can influence RNA splicing, a process in which RBMX is implicated. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a phosphatase inhibitor, which can indirectly lead to increased phosphorylation levels and thus activation of many proteins. This includes proteins within pathways that RBMX is implicated in, such as RNA splicing. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA (Phorbol 12-myristate 13-acetate) is a PKC activator. PKC activation can indirectly modulate RBMX function as PKC can influence RNA splicing, a process in which RBMX is actively involved. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased levels of protein phosphorylation. This can indirectly modulate RBMX function as it is implicated in processes regulated by phosphorylation. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin is a calcium ionophore, increasing intracellular calcium levels. Increased calcium can indirectly modulate RBMX function, as RBMX is implicated in calcium-mediated cellular processes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the SERCA pump, leading to increased intracellular calcium levels. Increased calcium can indirectly modulate RBMX function, as RBMX is implicated in calcium-mediated cellular processes. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 is an inhibitor of NF-κB activation, but it also induces the phosphorylation and activation of ERK, a component of the ERK/MAPK pathway. RBMX is involved in stress granule assembly, a process regulated by the ERK/MAPK pathway. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen Peroxide is a reactive oxygen species that can activate a multitude of signaling pathways, including the ERK/MAPK pathway. RBMX is involved in stress granule assembly, a process regulated by the ERK/MAPK pathway. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates phospholipase C, leading to increased intracellular calcium levels. Increased calcium can indirectly modulate RBMX function, as RBMX is implicated in calcium-mediated cellular processes. | ||||||