RBM18 Activators
Forskolin serves as a prime example, directly stimulating adenylate cyclase to raise cAMP levels, which in turn activates protein kinase A, a critical enzyme that phosphorylates and activates transcription factors associated with RBM18. 3-Isobutyl-1-methylxanthine preserves cAMP concentrations by inhibiting phosphodiesterases, thus prolonging the activated state of PKA and indirectly promoting RBM18 activity. Calcium signaling also plays a significant role, with ionomycin elevating intracellular calcium to activate kinases like calmodulin-dependent kinase, which may then phosphorylate proteins involved in RBM18 regulation. The activation of protein kinase C by compounds like PMA can also influence the phosphorylation status of proteins that modulate RBM18, suggesting a broad scope of kinase involvement in RBM18 activity.
Epigenetic modulation is another facet of this chemical class. Compounds such as 5-Azacytidine and Trichostatin A can alter the transcription of RBM18 by inhibiting DNA methyltransferases or histone deacetylases, respectively, creating a more favorable environment for gene expression. In the same vein, sodium butyrate enhances histone acetylation, potentially increasing the transcription of the RBM18 gene. Lithium chloride impacts the Wnt signaling pathway by inhibiting GSK-3, which may affect the expression of genes related to RBM18. Retinoic acid, by activating nuclear receptors, could modulate the expression of genes associated with RBM18. Inhibitors like SP600125 act on the MAPK pathway to alter the activity of transcription factors that regulate RBM18, while MG132 blocks the degradation of proteins involved in RBM18 regulation, stabilizing these regulatory factors and contributing to activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cAMP levels within the cell. Elevated cAMP may enhance the transcriptional activity of RBM18 by activating protein kinase A (PKA), which can phosphorylate transcription factors or coactivators associated with RBM18. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
This compound is a known inhibitor of phosphodiesterases, enzymes that break down cAMP. By inhibiting these enzymes, 3-Isobutyl-1-methylxanthine increases intracellular cAMP levels, thus activating PKA and potentially enhancing RBM18 transcriptional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which in turn may phosphorylate proteins involved in the regulation of RBM18, leading to its activation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is known to phosphorylate a wide range of target proteins. PKC activation can lead to the phosphorylation of factors that regulate RBM18 or modify its activity directly. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor that may lead to the demethylation of the RBM18 gene promoter region, facilitating its transcription. It can also alter the expression of various factors that regulate RBM18, leading to its activation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that can lead to a more relaxed chromatin state and increased accessibility of the RBM18 gene for transcriptional machinery. It can also modulate the activity of transcription factors and cofactors that regulate RBM18. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can influence the Wnt signaling pathway, which is linked to the regulation of gene expression and may include genes encoding RBM18 or its regulatory proteins. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate is a histone deacetylase inhibitor like Trichostatin A. It can lead to increased acetylation of histones, enhancing transcription of several genes, possibly including RBM18 or those of its regulatory proteins. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid affects gene expression by activating retinoic acid receptors (RARs). RARs can bind to retinoic acid response elements in the genome, potentially influencing the transcription of RBM18 or its associated regulatory proteins. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), part of the MAPK signaling pathway. By inhibiting JNK, SP600125 may alter the phosphorylation status of transcription factors or cofactors involved in RBM18 regulation, leading to its activation. | ||||||