RBM17 Activators
RBM17 activators are chemical compounds that enhance the activity of RNA Binding Motif Protein 17 (RBM17), a protein implicated in the regulation of alternative splicing, a critical process for generating protein diversity within cells. These activators interact with cellular signaling pathways that converge on the splicing machinery, modulating its components to increase the efficiency or alter the specificity of spliceosome assembly and function. For example, certain small molecule ligands can bind to modulatory proteins that interact with RBM17, stabilizing these interactions and enhancing RBM17's role in splice site selection. This results in a greater precision and variation in mRNA processing, leading to the production of different protein isoforms that can adapt cellular functions to various physiological needs. While the exact mechanisms of action may vary, the ultimate effect of these activators is to promote RBM17's participation in the splicing process, ensuring that the repertoire of mRNA-and consequently protein variants-is responsive to the cell's requirements.
The influence of RBM17 activators extends to the post-transcriptional modification of RNA as well, where RBM17 is known to play a pivotal role. These compounds may affect the assembly of the spliceosome by facilitating or stabilizing the binding of RBM17 to pre-mRNA substrates, thereby promoting the excision of introns and the ligation of exons. Some activators may work by altering the phosphorylation state of proteins in the spliceosome complex, indirectly increasing RBM17 activity by optimizing the splicing environment. Others might bind directly to RBM17, inducing conformational changes that enhance its RNA-binding affinity or its interaction with other spliceosome components.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP activates PKA, which can phosphorylate and influence various proteins, potentially including RBM17, thereby enhancing its activity within its specific pathway. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, increasing intracellular calcium concentration. This elevation can activate calcium-dependent kinase pathways such as calmodulin kinase, which might enhance the phosphorylation state and functional activity of RBM17. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). Activated PKC can phosphorylate various substrates, potentially including RBM17, thus enhancing its functional activity within cellular signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a potent antioxidant that can inhibit certain protein kinases, altering signaling pathways and potentially leading to the enhancement of RBM17 activity through reduced negative regulation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. Inhibition of PI3K can affect downstream AKT signaling, which may indirectly enhance the activity of RBM17 by altering the phosphorylation states of proteins within the pathway. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate engages with its G-protein-coupled receptors to activate intracellular signaling cascades that can lead to the activation of kinase pathways, potentially enhancing the functional activity of RBM17. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels, potentially enhancing RBM17 activity by activating calcium-dependent signaling pathways. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor that could lead to a change in the phosphorylation landscape, potentially enhancing RBM17 activity by reducing competitive phosphorylation or through feedback mechanisms. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor which could shift the balance of cellular signaling pathways, potentially leading to the enhancement of RBM17's role in splicing regulation by altering phosphorylation patterns. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 acts as an ionophore for divalent cations, particularly calcium, potentially enhancing RBM17 activity through elevated intracellular calcium levels and subsequent activation of calcium-dependent kinases. | ||||||