RASL10B inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of RASL10B, a member of the Ras-like small GTPase family. RASL10B, like other Ras-related proteins, acts as a molecular switch that regulates a wide range of cellular processes, including cell growth, differentiation, and intracellular signaling. It alternates between an active GTP-bound state and an inactive GDP-bound state, influencing various signaling cascades that control cellular responses to external stimuli. RASL10B is involved in the regulation of signaling pathways that contribute to the coordination of cellular processes such as proliferation, survival, and cytoskeletal dynamics. Inhibitors of RASL10B function by binding to its GTPase domain, preventing the exchange of GDP for GTP, or interfering with its ability to interact with downstream effectors, thus blocking its role in signaling.
The inhibition of RASL10B can have significant effects on cellular functions that rely on its regulatory activity. By disrupting the activation of RASL10B, these inhibitors interfere with the proper transmission of signals required for cell growth, adhesion, and movement. This can lead to changes in cytoskeletal organization and alterations in the way cells respond to their environment. Researchers use RASL10B inhibitors to study the specific roles of this GTPase in cellular signaling networks and to understand how it contributes to the maintenance of cellular architecture and function. These inhibitors provide insights into the broader mechanisms of Ras-like GTPase regulation, offering a deeper understanding of how these proteins modulate complex cellular pathways. Through the study of RASL10B inhibitors, scientists can explore how small GTPases like RASL10B are involved in fine-tuning intracellular communication, contributing to critical processes such as cellular growth control and motility.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
This farnesyltransferase inhibitor could hypothetically prevent the proper membrane association of RASL10B, thus hindering its functional expression. | ||||||
Lonafarnib | 193275-84-2 | sc-482730 sc-482730A | 5 mg 10 mg | $173.00 $234.00 | ||
By inhibiting farnesyltransferase, Lonafarnib may reduce RASL10B maturation and its subsequent localization within cellular membranes. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate could decrease RASL10B expression by hindering folate metabolism and nucleotide biosynthesis, essential for DNA replication and gene expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002, as a PI3K inhibitor, might downregulate RASL10B expression by disrupting the PI3K/AKT signaling pathway and its downstream effects on transcription factors. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin may decrease RASL10B expression by inhibiting mTOR, which is a key regulator of protein synthesis, cell growth, and cell cycle progression. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 may inhibit RASL10B expression by specifically targeting MEK1/2, leading to the downregulation of the MAPK/ERK signaling cascade. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin could decrease RASL10B expression through strong inhibition of PI3K, subsequently reducing the downstream signaling required for gene transcription. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $90.00 $251.00 | 5 | |
Zoledronic acid may reduce RASL10B expression by inhibiting farnesyl pyrophosphate synthase, which is crucial for the prenylation of many proteins, including those in the RAS family. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
By activating Nrf2, DL-Sulforaphane could downregulate RASL10B expression through antioxidant response element-mediated gene expression changes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been demonstrated to downregulate RASL10B expression by inhibiting NF-κB signaling, which is often linked to the transcriptional control of various genes. | ||||||