Date published: 2025-11-25

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RASL10B Inhibitors

RASL10B inhibitors are a class of chemical compounds specifically designed to target and inhibit the function of RASL10B, a member of the Ras-like small GTPase family. RASL10B, like other Ras-related proteins, acts as a molecular switch that regulates a wide range of cellular processes, including cell growth, differentiation, and intracellular signaling. It alternates between an active GTP-bound state and an inactive GDP-bound state, influencing various signaling cascades that control cellular responses to external stimuli. RASL10B is involved in the regulation of signaling pathways that contribute to the coordination of cellular processes such as proliferation, survival, and cytoskeletal dynamics. Inhibitors of RASL10B function by binding to its GTPase domain, preventing the exchange of GDP for GTP, or interfering with its ability to interact with downstream effectors, thus blocking its role in signaling.

The inhibition of RASL10B can have significant effects on cellular functions that rely on its regulatory activity. By disrupting the activation of RASL10B, these inhibitors interfere with the proper transmission of signals required for cell growth, adhesion, and movement. This can lead to changes in cytoskeletal organization and alterations in the way cells respond to their environment. Researchers use RASL10B inhibitors to study the specific roles of this GTPase in cellular signaling networks and to understand how it contributes to the maintenance of cellular architecture and function. These inhibitors provide insights into the broader mechanisms of Ras-like GTPase regulation, offering a deeper understanding of how these proteins modulate complex cellular pathways. Through the study of RASL10B inhibitors, scientists can explore how small GTPases like RASL10B are involved in fine-tuning intracellular communication, contributing to critical processes such as cellular growth control and motility.

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Manumycin A

52665-74-4sc-200857
sc-200857A
1 mg
5 mg
$215.00
$622.00
5
(1)

This farnesyltransferase inhibitor could hypothetically prevent the proper membrane association of RASL10B, thus hindering its functional expression.

Lonafarnib

193275-84-2sc-482730
sc-482730A
5 mg
10 mg
$173.00
$234.00
(0)

By inhibiting farnesyltransferase, Lonafarnib may reduce RASL10B maturation and its subsequent localization within cellular membranes.

Methotrexate

59-05-2sc-3507
sc-3507A
100 mg
500 mg
$92.00
$209.00
33
(5)

Methotrexate could decrease RASL10B expression by hindering folate metabolism and nucleotide biosynthesis, essential for DNA replication and gene expression.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY 294002, as a PI3K inhibitor, might downregulate RASL10B expression by disrupting the PI3K/AKT signaling pathway and its downstream effects on transcription factors.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin may decrease RASL10B expression by inhibiting mTOR, which is a key regulator of protein synthesis, cell growth, and cell cycle progression.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 may inhibit RASL10B expression by specifically targeting MEK1/2, leading to the downregulation of the MAPK/ERK signaling cascade.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin could decrease RASL10B expression through strong inhibition of PI3K, subsequently reducing the downstream signaling required for gene transcription.

Zoledronic acid, anhydrous

118072-93-8sc-364663
sc-364663A
25 mg
100 mg
$90.00
$251.00
5
(0)

Zoledronic acid may reduce RASL10B expression by inhibiting farnesyl pyrophosphate synthase, which is crucial for the prenylation of many proteins, including those in the RAS family.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$150.00
$286.00
$479.00
$1299.00
$8299.00
$915.00
22
(1)

By activating Nrf2, DL-Sulforaphane could downregulate RASL10B expression through antioxidant response element-mediated gene expression changes.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin has been demonstrated to downregulate RASL10B expression by inhibiting NF-κB signaling, which is often linked to the transcriptional control of various genes.