RAP Inhibitors
Receptor-associated protein (RAP) inhibitors constitute a class of chemical compounds designed to modulate cellular processes by targeting the receptor-associated protein. The receptor-associated protein, encoded by the RAP gene, is a multifunctional chaperone protein that plays a pivotal role in the intracellular trafficking and maturation of various cell surface receptors. These receptors are essential for the regulation of diverse physiological functions, ranging from cell growth and differentiation to immune response modulation. RAP, through its interaction with these receptors, facilitates their proper folding, assembly, and transportation to the cell surface.
By inhibiting the activity of RAP, RAP inhibitors disrupt this intricate process, leading to altered receptor functionality and downstream signaling cascades.RAP inhibitors is carefully designed to interfere with the binding interface between RAP and its target receptors. This interference impedes the chaperone function of RAP, disrupting its association with specific receptors and subsequently hindering their trafficking. Researchers have elucidated the significance of RAP in diverse cellular pathways, making RAP inhibitors valuable tools for studying the underlying molecular mechanisms.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1-Naphthyl PP1 | 221243-82-9 | sc-203765 sc-203765A | 10 mg 50 mg | $230.00 $964.00 | 3 | |
1-Naphthyl PP1 can inhibit farnesylation, a post-translational modification crucial for RAP protein's function. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $189.00 $822.00 | 2 | |
GGTI-298 can inhibit geranylgeranylation, another modification necessary for RAP protein activation. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $28.00 $88.00 $332.00 | 12 | |
Lovastatin can inhibit HMG-CoA reductase, the enzyme responsible for the synthesis of farnesyl pyrophosphate, a substrate needed for RAP protein prenylation. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $30.00 $87.00 $132.00 $434.00 | 13 | |
Like Lovastatin, Simvastatin can also inhibit HMG-CoA reductase, reducing the availability of farnesyl groups necessary for RAP protein function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 can inhibit MEK, a kinase that falls downstream of RAP in many signaling pathways. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 can inhibit both MEK1 and MEK2, disrupting downstream signaling of RAP. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin can inhibit PI3K, a kinase activated by RAP protein. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is another PI3K inhibitor, blocking a pathway activated by RAP protein. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Despite its name, Rapamycin can inhibit mTOR, a downstream effector of RAP protein. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is also an mTOR inhibitor, further disrupting RAP signaling. | ||||||