Molecular structure of 1-Naphthyl PP1, CAS Number: 221243-82-9
1-Naphthyl PP1 (CAS 221243-82-9)
See product citations (3)
Application:
1-Naphthyl PP1 is a selective inhibitor of v-Src and c-Fyn as well as c-Abl
CAS Number:
221243-82-9
Purity:
≥98%
Molecular Weight:
317.39
Molecular Formula:
C19H19N5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
1-Naphthyl PP1 is a selective inhibitor of the Src family of protein tyrosine kinases. It functions by binding to the ATP-binding site of the kinase, preventing the transfer of phosphate groups to tyrosine residues on target proteins. This inhibition disrupts the signaling pathways involved in cell proliferation, survival, and migration. Its mechanism of action involves blocking the activation of downstream signaling molecules, ultimately affecting cellular functions. 1-Naphthyl PP1 can be utilized to investigate the molecular mechanisms underlying various physiological and pathological processes, providing insights into the role of Src kinases in cellular signaling pathways.
1-Naphthyl PP1 (CAS 221243-82-9) References
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- Chemical genetic engineering of G protein-coupled receptor kinase 2. | Kenski, DM., et al. 2005. J Biol Chem. 280: 35051-61. PMID: 16081410
- A single amino-acid change in ERK1/2 makes the enzyme susceptible to PP1 derivatives. | Endo, S., et al. 2006. Biochem Biophys Res Commun. 341: 261-5. PMID: 16431218
- Aurora A is involved in central spindle assembly through phosphorylation of Ser 19 in P150Glued. | Reboutier, D., et al. 2013. J Cell Biol. 201: 65-79. PMID: 23547029
- PLK4 is a microtubule-associated protein that self-assembles promoting de novo MTOC formation. | Montenegro Gouveia, S., et al. 2018. J Cell Sci. 132: PMID: 30237222
- Transient c-Src Suppression During Endodermal Commitment of Human Induced Pluripotent Stem Cells Results in Abnormal Profibrotic Cholangiocyte-Like Cells. | Chaudhari, P., et al. 2019. Stem Cells. 37: 306-317. PMID: 30471152
- CKD Increases Carbonylation of HDL and Is Associated with Impaired Antiaggregant Properties. | Florens, N., et al. 2020. J Am Soc Nephrol. 31: 1462-1477. PMID: 32518085
- Application of Antibodies to Neuronally Expressed Nogo-A Increases Neuronal Survival and Neurite Outgrowth. | Nagaraj, V., et al. 2020. Int J Mol Sci. 21: PMID: 32751444
- Connection of core and tail Mediator modules restrains transcription from TFIID-dependent promoters. | Saleh, MM., et al. 2021. PLoS Genet. 17: e1009529. PMID: 34383744
- PoRal2 Is Involved in Appressorium Formation and Virulence via Pmk1 MAPK Pathways in the Rice Blast Fungus Pyricularia oryzae. | Qu, Y., et al. 2021. Front Plant Sci. 12: 702368. PMID: 34589096
- Protein Kinase D: A Potential Therapeutic Target in Prostate Cancer. | Roy, A. and Wang, QJ. 2017. Mol Cell Pharmacol. 9: 1-4. PMID: 34765081
- Nanchangmycin regulates FYN, PTK2, and MAPK1/3 to control the fibrotic activity of human hepatic stellate cells. | Li, W., et al. 2022. Elife. 11: PMID: 35617485
- Proteomic and Phosphoproteomic Profiling Reveals the Oncogenic Role of Protein Kinase D Family Kinases in Cholangiocarcinoma. | Lu, Y., et al. 2022. Cells. 11: PMID: 36231050
- Copper Death Inducer, FDX1, as a Prognostic Biomarker Reshaping Tumor Immunity in Clear Cell Renal Cell Carcinoma. | Jiang, A., et al. 2023. Cells. 12: PMID: 36766692
Inhibitor of:
c-Abl, c-Src, CABYR, CaMKI, CaMKII, Cdk2, Fyn, PCTAIRE-3, RAP, Ser/Thr Protein Kinase, SKAP55-R, SNAPC 45, and Tyrosine Kinase.Activator of:
CLK3, Nek11, and PP1α.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
1-Naphthyl PP1, 10 mg | sc-203765 | 10 mg | $235.00 | |||
1-Naphthyl PP1, 50 mg | sc-203765A | 50 mg | $983.00 |