RAM Inhibitors
RAM Inhibitors as a class, based on the assumption surrounding Notch signaling, primarily focus on the modulation of the Notch pathway, either directly or indirectly. Most of the chemicals described, such as DAPT, DBZ, and Compound E, achieve their inhibitory role by targeting the γ-secretase enzyme, a pivotal component for Notch receptor activation. By blocking this enzyme, these inhibitors effectively prevent the cleavage and subsequent activation of the Notch receptor, leading to a cascade of effects on downstream signaling components, including those that contain RAM domains.
In addition to γ-secretase-centric mechanisms, there are other inhibitors like FLI-06 and SAHM1 that take alternative routes. For instance, FLI-06 hinders Notch signaling by influencing endocytosis, thereby impacting the availability and functionality of Notch receptors on the cell surface. SAHM1, on the other hand, has been designed to directly impede the Notch transcription complex, thereby dampening the pathway's downstream effects.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
γ-secretase inhibitor that prevents Notch receptor cleavage and activation. Since RAM domain-containing proteins are associated with Notch, inhibiting the pathway can indirectly modulate their activity. | ||||||
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $100.00 $260.00 | 4 | |
Another potent γ-secretase inhibitor that stops Notch signaling. By curtailing the pathway, it indirectly influences RAM-associated proteins' functionality. | ||||||
Compound E | 209986-17-4 | sc-221433 sc-221433A sc-221433B | 250 µg 1 mg 5 mg | $122.00 $335.00 $948.00 | 12 | |
An inhibitor of γ-secretase which prevents Notch activation. By disrupting the Notch pathway, it can indirectly impact proteins related to or affected by the Notch signal, including potential RAM domain-containing ones. | ||||||
LY411575 | 209984-57-6 | sc-364529 sc-364529A | 10 mg 50 mg | $194.00 $464.00 | 6 | |
γ-secretase inhibitor known to effectively block Notch signaling. Indirect modulation of RAM domain proteins can be inferred by hindering this pathway. | ||||||
RO-4929097 | 847925-91-1 | sc-364602 sc-364602A | 10 mg 50 mg | $430.00 $1389.00 | 1 | |
Another inhibitor targeting γ-secretase, subsequently disrupting Notch signaling. Indirect influence on RAM domain proteins occurs as the Notch pathway is perturbed. | ||||||
FLI-06 | 313967-18-9 | sc-497529 | 5 mg | $82.00 | ||
An inhibitor that disrupts Notch signaling by affecting endocytosis. By hampering Notch activity at this level, the indirect effect on associated RAM domain proteins is plausible. | ||||||
SAHM1 | 2050906-89-1 | sc-507534 | 5 mg | $1435.00 | ||
Designed peptide that inhibits the Notch transcription complex. This interference can lead to an indirect impact on RAM domain-containing proteins associated with the Notch pathway. | ||||||
PF-3084014 | 1290543-63-3 | sc-507501 | 5 mg | $130.00 | ||
γ-secretase inhibitor which blocks Notch receptor cleavage and activation. RAM domain proteins linked to Notch might be influenced indirectly by the action of this compound. | ||||||
BMS-708163 | 1146699-66-2 | sc-364444 sc-364444A | 10 mg 50 mg | $480.00 $1455.00 | 1 | |
Inhibitor specifically designed for γ-secretase, thereby affecting Notch signaling. It can have an indirect influence on proteins associated with the Notch pathway, potentially including RAM domain-containing ones. | ||||||
MK-0752 | 471905-41-6 | sc-364534 sc-364534A | 10 mg 50 mg | $592.00 $1550.00 | ||
A potent inhibitor of γ-secretase, this compound acts to interrupt the Notch signaling cascade. This disruption can potentially lead to the indirect modulation of RAM domain proteins linked to the Notch pathway. | ||||||