LY411575 CAS: 209984-57-6
MF: C26H23F2N3O4
MW: 479.48
A potent γ-secretase inhibitor.

LY411575 (CAS 209984-57-6)

LY411575 | CAS 209984-57-6 is rated 5.0 out of 5 by 1.
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Synonym: LY-411575
Application: A potent γ-secretase inhibitor
CAS Number: 209984-57-6
Purity: ≥98%
Molecular Weight: 479.48
Molecular Formula: C26H23F2N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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LY-411575 is an inhibitor of γ-secretase, which can be assessed by substrates like Notch S3 cleavage and amyloid precursor protein (APP). LY-411575 blocks Notch activation and causes apoptosis in primary and immortalized KS cells.

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
328.47° C (Predicted)
Boiling Point :
~836.0° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10435235
SMILES :
C[[email protected]@H](C(=O)N[[email protected]]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[[email protected]](C4=CC(=CC(=C4)F)F)O

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LY411575  Product Citations

See how others have used LY411575. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27845051  Iida, H. et al. 2017. Dev. Biol. 421: 118-125.

PMID: # 29343879  Akiyama, S.|Mochizuki, W.|Nibe, Y.|Matsumoto, Y.|Sakamoto, K.|Oshima, S.|Watanabe, M.|Nakamura, T.| et al. 2017. Acta Histochem Cytochem. 50: 159-168.

PMID: # 27605621  Hu, L.|Lu, J.|Chiang, H.|Wu, H.|Edge, AS.|Shi, F.| et al. 2016. J. Neurosci. 36: 9479-89.

PMID: # 24642408  Lush, ME. et al. 2014. eLife. 3: e01832.

PMID: # 23312516  Mizutari, K. et al. 2013. Neuron. 77: 58-69.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Mizutari Mizutari, et al. (PubMed ID 23312516) compared potency of LY411575 with other known drugs for their effect on hair cell differentiation from utricular spheres (from neonatal Math1-nGFP reporter mice). LY411575 was reported to be the most potent. -SCBT Publication Review
Date published: 2015-04-16
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