Molecular structure of LY411575, CAS Number: 209984-57-6
LY411575 (CAS 209984-57-6)
See product citations (6)
Alternate Names:
LY-411575
Application:
LY411575 is a potent γ-secretase inhibitor
CAS Number:
209984-57-6
Purity:
≥98%
Molecular Weight:
479.48
Molecular Formula:
C26H23F2N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
LY411575 is a noteworthy small molecule serving as a peptide-mimetic inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. The mechanism of action of LY411575 involves its binding to the ATP binding site of the LY411575 tyrosine kinase, consequently inhibiting its activity. As a result, downstream signaling pathways that drive cell growth and proliferation are impeded, leading to the inhibition of these vital cellular processes.
LY411575 (CAS 209984-57-6) References
- Novel orally active, dibenzazepinone-based gamma-secretase inhibitors. | Peters, JU., et al. 2007. Bioorg Med Chem Lett. 17: 5918-23. PMID: 17869099
- A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers. | Fauq, AH., et al. 2007. Bioorg Med Chem Lett. 17: 6392-5. PMID: 17897827
- pPKCα-mediated effect on in vitro Aβ production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes. | Sozio, P., et al. 2012. J Biol Regul Homeost Agents. 26: 245-51. PMID: 22824752
- Notch signaling modulates proliferative vitreoretinopathy via regulating retinal pigment epithelial-to-mesenchymal transition. | Zhang, J., et al. 2017. Histochem Cell Biol. 147: 367-375. PMID: 27600720
- Inhibitory effect of presenilin inhibitor LY411575 on maturation of hepatitis C virus core protein, production of the viral particle and expression of host proteins involved in pathogenicity. | Otoguro, T., et al. 2016. Microbiol Immunol. 60: 740-753. PMID: 27797115
- Gamma-Secretase Inhibitors Attenuate Neurotrauma and Neurogenic Acute Lung Injury in Rats by Rescuing the Accumulation of Hypertrophic Microglia. | Lin, HJ., et al. 2017. Cell Physiol Biochem. 44: 1726-1740. PMID: 29227981
- LY411575, a potent γ-secretase inhibitor, suppresses osteoclastogenesis in vitro and LPS-induced calvarial osteolysis in vivo. | Chen, X., et al. 2019. J Cell Physiol. 234: 20944-20956. PMID: 31020651
- Notch-1 and Notch-3 Mediate Hypoxia-Induced Activation of Synovial Fibroblasts in Rheumatoid Arthritis. | Chen, J., et al. 2021. Arthritis Rheumatol. 73: 1810-1819. PMID: 33844448
- Identification of MAEL as a promoter for the drug resistance model of iPSCs derived from T-ALL. | Chen, X., et al. 2022. Cancer Med. 11: 3479-3490. PMID: 35488386
- γ-secretase inhibitors augment efficacy of BCMA-targeting bispecific antibodies against multiple myeloma cells without impairing T-cell activation and differentiation. | Chen, H., et al. 2022. Blood Cancer J. 12: 118. PMID: 35973981
- Tibetan medicine Qi-Sai-Er-Sang-Dang-Song Decoction inhibits TNF-α-induced rheumatoid arthritis in human fibroblast-like synoviocytes via regulating NOTCH1/NF-κB/NLRP3 pathway. | Su, J., et al. 2023. J Ethnopharmacol. 310: 116402. PMID: 36966850
- Gamma secretase activity modulates BMP-7-induced dendritic growth in primary rat sympathetic neurons. | Karunungan, K., et al. 2023. Auton Neurosci. 247: 103085. PMID: 37031474
- Cisplatin attenuates taste cell homeostasis and induces inflammatory activation in the circumvallate papilla. | Ren, W., et al. 2023. Theranostics. 13: 2896-2913. PMID: 37284449
Inhibitor of:
ANKRD50, Aph-1c, ASCL1, Atg16, Csl, Deltex (DTX; E3 ubiquitin ligase), ENHO, fringe, Gamma-secretase, GATA-5, HES4, HES5, HES6, HES7, HoxA5, HRT1_Hrt1, Jagged, LAP3, Manic Fringe, NET-7, NEURL, NLE1, Notch, Nrarp, Olfr804, OTTMUSG00000007521, OTTMUSG00000007655, Penumbra, PION, Radical Fringe, RAM, RBP-L, SPPase2, TLE5, Vmn1r170, Vmn1r39, and Vmn1r94.Activator of:
Annexin A10, Aph-1c, C14orf135, Deltex-3, EG-VEGF, Mam1, Notch 2, and Pecanex 2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LY411575, 10 mg | sc-364529 | 10 mg | $194.00 | |||
LY411575, 50 mg | sc-364529A | 50 mg | $464.00 |