Molecular structure of Compound E, CAS Number: 209986-17-4
Compound E (CAS 209986-17-4)
See product citations (12)
Alternate Names:
Compound E is also known as γ-Secretase Inhibitor XXI.
Application:
Compound E is a cell permeable non-competitive γ-secretase inhibitor that regulates signaling pathways.
CAS Number:
209986-17-4
Purity:
≥98%
Molecular Weight:
490.50
Molecular Formula:
C27H24F2N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Compound E is a cell permeable non-competitive inhibitor of γ-secretase. Studies indicate that Compound E is a multifunctional transmembrane protein complex that enzymatically catalyzes the cleavage of single-pass transmembrane proteins. One of the most common substrates for Compound E is amyloid precursor protein. Compound E is also known as γ-Secretase Inhibitor, γ-Secretase Inhibitor XXI, GSI, and N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-benzeneacetamide.
Compound E (CAS 209986-17-4) References
- Presenilin-1 and -2 are molecular targets for gamma-secretase inhibitors. | Seiffert, D., et al. 2000. J Biol Chem. 275: 34086-91. PMID: 10915801
- Presenilin-dependent gamma-secretase activity modulates thymocyte development. | Doerfler, P., et al. 2001. Proc Natl Acad Sci U S A. 98: 9312-7. PMID: 11470902
- Pharmacological knock-down of the presenilin 1 heterodimer by a novel gamma -secretase inhibitor: implications for presenilin biology. | Beher, D., et al. 2001. J Biol Chem. 276: 45394-402. PMID: 11574530
- gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. | Ni, CY., et al. 2001. Science. 294: 2179-81. PMID: 11679632
- Postprandial hypoglycemia. Fact or fiction? | Hofeldt, FD., et al. 1975. JAMA. 233: 1309. PMID: 1174196
- Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines. | Tian, G., et al. 2002. J Biol Chem. 277: 31499-505. PMID: 12072428
- aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. | Francis, R., et al. 2002. Dev Cell. 3: 85-97. PMID: 12110170
- Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. | Murakami, D., et al. 2003. Oncogene. 22: 1511-6. PMID: 12629514
- Regulated intramembrane proteolysis of the p75 neurotrophin receptor modulates its association with the TrkA receptor. | Jung, KM., et al. 2003. J Biol Chem. 278: 42161-9. PMID: 12913006
- Linking receptor-mediated endocytosis and cell signaling: evidence for regulated intramembrane proteolysis of megalin in proximal tubule. | Zou, Z., et al. 2004. J Biol Chem. 279: 34302-10. PMID: 15180987
- Nicastrin, presenilin, APH-1, and PEN-2 form active gamma-secretase complexes in mitochondria. | Hansson, CA., et al. 2004. J Biol Chem. 279: 51654-60. PMID: 15456764
- Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. | Weng, AP., et al. 2004. Science. 306: 269-71. PMID: 15472075
- Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein. | Zhao, G., et al. 2004. J Biol Chem. 279: 50647-50. PMID: 15485850
- Determination of guinea-pig cortical gamma-secretase activity ex vivo following the systemic administration of a gamma-secretase inhibitor. | Grimwood, S., et al. 2005. Neuropharmacology. 48: 1002-11. PMID: 15857627
Inhibitor of:
A830010M20Rik, Csl, Gamma-secretase, HES4, HES7, HoxA5, IDE, ITM2A, Jagged1, kismet-L, NET-7, NUMB, Radical Fringe, RAM, RBP-Jκ, Reg γ, Sly1, SOC1, SPPase2, TLE2, Tra-3, and WRM-1.Activator of:
Aph-1c, C14orf135, Delta, Hairless, and Lunatic Fringe.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Compound E, 250 µg | sc-221433 | 250 µg | $122.00 | |||
Compound E, 1 mg | sc-221433A | 1 mg | $335.00 | |||
Compound E, 5 mg | sc-221433B | 5 mg | $948.00 |