RAM Activators
The chemical class known as RAM activators encompasses specific compounds that can indirectly influence the activation of Rab-27A, a GTPase critical for vesicle trafficking processes. These activators work through a range of mechanisms that affect Rab-27A's GTP-binding state, membrane association, and interaction with effector proteins, thereby modulating its activation without directly binding as ligands to Rab-27A itself.
For example, GTP analogs such as GTPγS lock Rab-27A in an active GTP-bound state, providing a continuous signal for vesicle trafficking. Similarly, altering the concentration of cellular magnesium using Magnesium chloride can affect the GTPase's activity by enhancing its GTP-bound state. Compounds that modulate the lipid environment of Rab-27A, such as D-erythro-Sphingosine and DiC8-PIP2, have the potential to impact its localization and activation state indirectly. Additionally, the use of specific kinase activators like 8-Bromo-cAMP indicates the possibility of phosphorylation-dependent regulation of Rab-27A's activity. Furthermore, the inclusion of inhibitors like GGTI-298 and 2-Bromopalmitate implies that preventing post-translational modifications of Rab-27A or its associated proteins can lead to altered localization and function. Lastly, influencing cytoskeletal dynamics through the use of ML141 suggests the interconnected nature of intracellular signaling pathways in controlling Rab-27A activation.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $88.00 $190.00 $500.00 $2400.00 $9200.00 $15000.00 | 2 | |
A bioactive sphingolipid that can influence membrane lipid composition, potentially affecting Rab-27A’s subcellular localization and function in vesicle trafficking. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
A cAMP analog that can activate PKA, which may phosphorylate downstream targets involved in the regulation of Rab-27A, thereby influencing its activity indirectly. | ||||||
XL-184 free base | 849217-68-1 | sc-364657 sc-364657A | 5 mg 10 mg | $92.00 $204.00 | 1 | |
A synthetic, soluble form of PIP2 that can interact with Rab-27A associated proteins, potentially altering Rab-27A activation and vesicle trafficking. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Essential for the activity of GTPases, including Rab-27A, by stabilizing the GTP-bound state; increasing the concentration of magnesium can facilitate the activation of Rab-27A. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $187.00 $670.00 | 11 | |
While it primarily targets the ARF-family, this compound disrupts Golgi apparatus function and could alter vesicle trafficking in a way that compensates with increased Rab-27A activity. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $189.00 $822.00 | 2 | |
Inhibits geranylgeranylation of small GTPases, which could result in the accumulation of unprenylated Rab-27A, potentially leading to its mislocalization and aberrant activation. | ||||||
Spectinomycin dihydrochloride pentahydrate | 22189-32-8 | sc-203279 sc-203279A | 5 g 10 g | $82.00 $120.00 | 9 | |
A nitric oxide donor that can modulate signaling pathways, potentially influencing Rab-27A activity through redox-dependent processes. | ||||||
2-Bromohexadecanoic acid | 18263-25-7 | sc-251714 sc-251714A | 10 g 50 g | $52.00 $197.00 | 4 | |
A palmitoylation inhibitor that could alter the palmitoylation status of proteins interacting with Rab-27A, thereby affecting Rab-27A activity indirectly. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Can affect GTPase activity by disrupting inositol phosphate metabolism, possibly influencing Rab-27A's cellular localization and activity. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
Although an inhibitor of Cdc42, ML141 may influence Rab-27A by modifying actin dynamics and subsequently affecting vesicle trafficking mechanisms Rab-27A is associated with. | ||||||