Molecular structure of SAHM1, CAS Number: 2050906-89-1
SAHM1 (CAS 2050906-89-1)
Alternate Names:
(4S)-4-[[(2S)-2-acetamidopropanoyl]amino]-5-[[(2S)-5-carbamimidamido-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(2S)-5-carbamimidamido-1-[[(2S,3S)-1-[[(3S,6R,9S,12S,16Z,21S)-3-(3-carbamimidamidopropyl)-21-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]carbamoyl]-12,21-dimethyl-9-(2-methylpropyl)-2,5,8,11-tetraoxo-6-(sulfanylmethyl)-1,4,7,10-tetrazacyclohenicos-16-en-12-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-5-oxopentanoic acid
CAS Number:
2050906-89-1
Molecular Weight:
2196.60
Molecular Formula:
C94H162N36O23S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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SAHM1 (CAS 2050906-89-1) References
- Direct inhibition of the NOTCH transcription factor complex. | Moellering, RE., et al. 2009. Nature. 462: 182-8. PMID: 19907488
- γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells. | Séveno, C., et al. 2012. Breast Cancer Res. 14: R96. PMID: 22703841
- Notch-signalling is required for head regeneration and tentacle patterning in Hydra. | Münder, S., et al. 2013. Dev Biol. 383: 146-57. PMID: 24012879
- The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. | KleinJan, A., et al. 2018. J Allergy Clin Immunol. 142: 76-85.e8. PMID: 29111218
- Notch Inhibition Prevents Differentiation of Human Limbal Stem/Progenitor Cells in vitro. | González, S., et al. 2019. Sci Rep. 9: 10373. PMID: 31316119
- Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes. | Xiao, C., et al. 2020. Brain Behav Immun. 88: 184-192. PMID: 32330594
- Laminin-integrin a6b4 interaction activates notch signaling to facilitate bladder cancer development. | Hao, N., et al. 2022. BMC Cancer. 22: 558. PMID: 35585515
- Genetic interference with HvNotch provides new insights into the role of the Notch-signalling pathway for developmental pattern formation in Hydra. | Pan, Q., et al. 2024. Sci Rep. 14: 8553. PMID: 38609434
Inhibitor of:
ENHO, FKBP51, Jagged1, RAM, and RBP-Jκ.Activator of:
Lunatic Fringe, MAML2, and Radical Fringe.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SAHM1, 5 mg | sc-507534 | 5 mg | $1435.00 |