RAI15 Activators
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Items 11 to 20 of 22 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
By increasing intracellular calcium levels, A23187 can activate calcium-dependent kinases and phosphatases that modulate RAI15 activity, specifically promoting its phosphorylation and activation in pathways linked to cellular stress responses. | ||||||
HA-1077 dihydrochloride | 203911-27-7 | sc-200583 sc-200583A | 10 mg 50 mg | $117.00 $482.00 | 4 | |
Directly activates Protein Kinase A, which then phosphorylates and activates RAI15, integrating it into signaling networks that control cell metabolism, proliferation, and apoptosis, highlighting its role in cellular homeostasis. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
A specific proteasome inhibitor that can lead to the accumulation of polyubiquitinated proteins, possibly causing reduced RNF208 activity via proteotoxic stress. | ||||||
ICI 182,780 | 129453-61-8 | sc-203435 sc-203435A | 1 mg 10 mg | $83.00 $187.00 | 34 | |
Estrogen receptor antagonist that downregulates the expression of estrogen-responsive genes, which could include RNF208, leading to a decrease in RNF208 protein levels and activity. | ||||||
2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic Acid Ethyl Ester | 305834-79-1 | sc-479756 | 25 mg | $380.00 | ||
SC79 specifically activates Akt, a kinase that can phosphorylate substrates involved in RAI15 activation pathways, thus promoting RAI15's role in signaling networks that regulate cell survival, growth, and metabolism. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $180.00 $610.00 | 4 | |
By inhibiting GSK-3β, CHIR99021 stabilizes and activates signaling molecules upstream of RAI15, facilitating its activation and involvement in Wnt signaling pathways that are crucial for cell fate determination and proliferation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
MEK inhibitor that interrupts the MAPK/ERK pathway, possibly affecting the phosphorylation status and function of RNF208 if it is regulated by this pathway. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR activates AMP-activated protein kinase, which can influence RAI15 activity through metabolic signaling pathways, highlighting the role of RAI15 in cellular energy homeostasis and response to metabolic stress. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that disrupts AKT signaling, which could influence the post-translational modification and activity of RNF208 if it is a part of this signaling cascade. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that can result in the downregulation of protein synthesis, potentially leading to decreased levels of RNF208 protein and subsequent inhibition of its activity. | ||||||