RAI15 Activators
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Items 1 to 10 of 22 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that increases acetylation levels of histones, thereby potentially altering the chromatin structure and affecting the transcription of RNF208. This can lead to reduced RNF208 protein levels and activity due to changes in gene expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. Elevated cAMP promotes protein kinase A (PKA) activation, which can phosphorylate and activate RAI15 by enhancing its protein-protein interactions and functional activity within cellular signaling pathways. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX inhibits phosphodiesterases, preventing cAMP degradation. This indirectly increases cAMP levels, thereby enhancing PKA activity. PKA activation is a critical step in phosphorylating RAI15, leading to its functional activation and integration into signaling cascades that regulate cell functions. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
Proteasome inhibitor that prevents the degradation of ubiquitinated proteins, which may include RNF208, leading to its inactivity due to aggregation or misfolding. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram specifically inhibits phosphodiesterase 4 (PDE4), leading to an increase in cAMP levels within cells. The resultant PKA activation can phosphorylate RAI15, thus promoting its activation and participation in cellular signaling pathways that influence various biological processes. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor that can lead to the accumulation of ubiquitinated RNF208, potentially causing cellular stress and downregulation of RNF208 activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Lysosome acidification inhibitor that can result in the disruption of lysosomal degradation pathways, possibly impacting the turnover of RNF208 and reducing its functional activity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Topoisomerase II inhibitor that induces DNA damage and can influence the ubiquitin-proteasome system, potentially affecting RNF208 stability and function. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $106.00 $166.00 $289.00 $550.00 $819.00 | 2 | |
Activates CREB by increasing cAMP levels, leading to the transcription of genes that encode proteins interacting with RAI15, thus enhancing its functional activation and role in signaling pathways that govern cell cycle and survival. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
NEDD8-activating enzyme inhibitor that prevents neddylation, a process that can modify RNF208, thus potentially reducing its activity by affecting its conformation or stability. | ||||||