HA-1077 dihydrochloride (CAS 203911-27-7)
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HA-1077 dihydrochloride, also known as fasudil, is a potent inhibitor of Rho kinases (ROCK), a family of serine/threonine kinases studied regarding various cellular functions such as contraction, motility, proliferation, and apoptosis. In research, HA-1077 dihydrochloride is extensively used to study the role of ROCK in cytoskeletal organization and cell adhesion, as well as in vascular endothelial function and smooth muscle contraction. Its ability to inhibit ROCK activity allows for the exploration of the pathophysiological implications of this kinase in various conditions. Additionally, HA-1077 dihydrochloride serves as a chemical tool to dissect the molecular pathways that contribute to neurodegenerative diseases and central nervous system injuries where ROCK is suggested to play a part.
HA-1077 dihydrochloride (CAS 203911-27-7) References
- Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. | Nagumo, H., et al. 2000. Am J Physiol Cell Physiol. 278: C57-65. PMID: 10644512
- Inhibition of myosin light chain phosphorylation in cultured smooth muscle cells by HA1077, a new type of vasodilator. | Sasaki, Y. and Sasaki, Y. 1990. Biochem Biophys Res Commun. 171: 1182-7. PMID: 2222437
- Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. | Asano, T., et al. 1989. Br J Pharmacol. 98: 1091-100. PMID: 2611484
- Mechanism of action of a novel antivasospasm drug, HA1077. | Asano, T., et al. 1987. J Pharmacol Exp Ther. 241: 1033-40. PMID: 3598899
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HA-1077 dihydrochloride, 10 mg | sc-200583 | 10 mg | $117.00 | |||
HA-1077 dihydrochloride, 50 mg | sc-200583A | 50 mg | $482.00 |