RABAPTIN-5 Inhibitors
RABAPTIN-5 inhibitors belong to a distinct chemical class renowned for their pivotal role in modulating intracellular trafficking processes. At the molecular level, these inhibitors exert their effects by specifically targeting RABAPTIN-5, a crucial component of the Rab GTPase family. Rab GTPases are integral regulators of vesicular transport, orchestrating the intricate movements of membrane-bound vesicles between cellular compartments. RABAPTIN-5, as an effector protein, plays a central role in tethering vesicles and facilitating their fusion with target membranes.
The inhibitors act by disrupting the interaction between RABAPTIN-5 and other essential cellular components, thereby impeding the normal progression of vesicular transport.RABAPTIN-5 inhibitors is intricately linked to their ability to interfere with protein-protein interactions within the cell. Through a series of structural modifications and binding events, these inhibitors selectively hinder the association between RABAPTIN-5 and its interacting partners, hindering the normal functioning of the vesicular transport machinery. Consequently, the inhibition of RABAPTIN-5 serves as a molecular switch that disrupts the finely tuned orchestration of cellular trafficking events.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a covalent inhibitor of PI3K, a kinase upstream of Rab5. By inhibiting PI3K, Wortmannin can reduce Rab5 activation, indirectly affecting Rabaptin-5. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3K inhibitor. Similar to Wortmannin, its inhibitory effect on PI3K can lead to reduced Rab5 activity, indirectly inhibiting Rabaptin-5. | ||||||
Zoledronic acid, anhydrous | 118072-93-8 | sc-364663 sc-364663A | 25 mg 100 mg | $92.00 $256.00 | 5 | |
Zoledronic Acid inhibits farnesyl pyrophosphate synthase, which is necessary for Rab5 prenylation and activation. By inhibiting this process, Zoledronic Acid can reduce Rab5 activity and thereby, Rabaptin-5's function. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $219.00 $634.00 | 5 | |
Manumycin A is an inhibitor of farnesyltransferase, another enzyme involved in Rab5 activation. It can therefore indirectly affect Rabaptin-5. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $193.00 $838.00 | 2 | |
GGTI-298 inhibits geranylgeranyltransferase I, which is required for Rab5 prenylation. Inhibiting this enzyme can lead to reduced Rab5 activity and Rabaptin-5's function. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-MA is an inhibitor of PI3K, the kinase that activates Rab5. It's another indirect inhibitor of Rabaptin-5. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 inhibits vacuolar H+-ATPase, which is necessary for endosome acidification, a process Rab5 and Rabaptin-5 are involved in. | ||||||
Concanamycin A | 80890-47-7 | sc-202111 sc-202111A sc-202111B sc-202111C | 50 µg 200 µg 1 mg 5 mg | $66.00 $167.00 $673.00 $2601.00 | 109 | |
Concanamycin A also inhibits vacuolar H+-ATPase, thus can indirectly inhibit Rabaptin-5 function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore inhibits dynamin, which is required for endocytic vesicle formation. This can affect Rab5 and Rabaptin-5 function. | ||||||
Pitstop 2 | 1419320-73-2 | sc-507418 | 10 mg | $360.00 | ||
Pitstop 2 inhibits clathrin-mediated endocytosis, which Rab5 and Rabaptin-5 are involved in. | ||||||