Rab11-FIP5 Activators
The Rab11-FIP5 protein plays a crucial role in the complex orchestration of endosomal recycling, and its modulation is not isolated but intertwined with a broad range of cellular processes. Brefeldin A, Monensin, and Nigericin, for instance, all target distinct facets of the endosome and Golgi dynamics, emphasizing the intricate link between these organelles and the protein in question. Such compounds exert indirect control, altering the very environment in which Rab11-FIP5 operates, thereby modulating its activity.
Furthermore, vesicular trafficking, a central theme for Rab11-FIP5, is an intricate dance of cytoskeletal and membranous components. Disruptors like Dynasore, Latrunculin A, and Vinblastine can skew these pathways, offering another avenue to influence Rab11-FIP5. EGF, with its receptor-mediated endocytosis, shows the to loop in Rab11-FIP5 indirectly. U18666A, ML141, and Manumycin A underscore the interconnectedness of vesicular transport pathways, with each affecting unique nodes but converging on shared pathways. Chloroquine, by altering endosomal pH, offers yet another layer of modulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
Disrupts the Golgi apparatus which can affect endosomal recycling, potentially involving Rab11-FIP5. | ||||||
Nigericin sodium salt | 28643-80-3 | sc-201518A sc-201518 sc-201518B sc-201518C sc-201518D | 1 mg 5 mg 25 mg 1 g 5 g | $45.00 $110.00 $235.00 $6940.00 $26879.00 | 9 | |
Affects pH within endosomes, influencing endosomal recycling and potentially Rab11-FIP5. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3-kinase inhibitor which can affect vesicular trafficking pathways and thereby possibly Rab11-FIP5. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Disrupts actin filaments and can thus modulate endocytosis, possibly influencing Rab11-FIP5's role in endosomal recycling. | ||||||
Vinblastine Sulfate | 143-67-9 | sc-201447 sc-201447A sc-201447B sc-201447C | 10 mg 50 mg 100 mg 1 g | $107.00 $404.00 $550.00 $2200.00 | 9 | |
Microtubule disrupting agent which can influence vesicle trafficking pathways, potentially impacting Rab11-FIP5. | ||||||
U 18666A | 3039-71-2 | sc-203306 sc-203306A | 10 mg 50 mg | $140.00 $500.00 | 2 | |
Induces cholesterol accumulation in late endosomes and lysosomes, possibly influencing Rab11-FIP5. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $134.00 $502.00 | 7 | |
A specific inhibitor of Cdc42, another small GTPase, which can impact vesicle trafficking and thereby Rab11-FIP5. | ||||||
Manumycin A | 52665-74-4 | sc-200857 sc-200857A | 1 mg 5 mg | $215.00 $622.00 | 5 | |
An inhibitor of farnesyltransferase which can affect Rab protein prenylation and influence Rab11-FIP5's activity. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Alters endosomal pH which can impact endosomal recycling and potentially influence Rab11-FIP5's function. | ||||||