Rab11-FIP5 Inhibitors
Rab11-FIP5 inhibitors are chemical compounds that target and inhibit the function of Rab11-FIP5, a key effector protein involved in the regulation of endosomal recycling. Rab11-FIP5 is part of the Rab11 family interacting proteins (FIPs) that mediate interactions between Rab11 GTPase and various components of the cellular trafficking machinery. Rab11-FIP5 plays a crucial role in the recycling of cargo proteins back to the plasma membrane from recycling endosomes. By inhibiting Rab11-FIP5, these compounds can effectively disrupt the recycling pathway, which has implications for processes such as membrane receptor recycling, cargo transport, and the maintenance of cellular polarity.
In research settings, Rab11-FIP5 inhibitors have been employed to study the mechanisms of endosomal recycling and their impact on intracellular trafficking and signal transduction. Disruption of Rab11-FIP5 activity allows scientists to explore the downstream consequences of altered vesicle recycling, such as changes in receptor availability on the cell surface, and the effects on cell communication and nutrient uptake. These inhibitors provide valuable insights into the dynamics of membrane trafficking, including the coordination between endocytosis and recycling pathways. Furthermore, studies utilizing Rab11-FIP5 inhibitors contribute to understanding how dysregulated endosomal recycling impacts broader cellular processes such as cell division, migration, and differentiation, making them an essential tool for investigating complex cellular behaviors.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA, potentially affecting the transcription of genes, including Rab11-FIP5, impacting intracellular trafficking. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide inhibits protein synthesis, possibly affecting the overall expression of Rab11-FIP5 and its participation in cellular trafficking. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 inhibits the proteasome, possibly altering the degradation of Rab11-FIP5 or proteins interacting with it. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubules, potentially affecting the transport roles of Rab11-FIP5 within the cell. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
Monensin is an ionophore affecting cellular transport, which may indirectly impact the trafficking roles of Rab11-FIP5. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK, affecting cytoskeleton dynamics and possibly the trafficking function of Rab11-FIP5. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds tubulin, affecting microtubule dynamics and potentially the role of Rab11-FIP5 in transport processes. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $87.00 | 44 | |
Dynasore inhibits dynamin, potentially affecting endocytosis and the roles of Rab11-FIP5 in intracellular trafficking. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Nystatin affects membrane integrity, potentially influencing vesicular trafficking involving Rab11-FIP5. | ||||||