Rab 4B Activators
Rab 4B activators pertain to a class of chemical compounds that modulate the activity of the Rab 4B protein, a member of the larger Rab family of small GTPases. These proteins play crucial roles in the regulation of intracellular vesicle trafficking, particularly in the processes of endocytosis and the recycling of membranes and proteins back to the cell surface. Rab 4B, specifically, is implicated in the fast recycling of receptors and other proteins to and from the plasma membrane. The activators of this protein influence its ability toRab 4B activators are a category of chemical compounds that interact with the Rab 4B protein, which is a part of the Rab family of small GTPases. These proteins have essential roles in the regulation of vesicular trafficking within eukaryotic cells. Rab 4B, in particular, is involved in the intricate processes of endocytosis and recycling pathways, which are critical for the proper distribution and function of membrane proteins and lipids. It is involved in the fast recycling of endosomal contents back to the cell surface, a process necessary for the dynamic regulation of cellular responses to environmental changes. Activators of Rab 4B enhance the protein's natural function by promoting its active GTP-bound state, which is required for its interaction with effector proteins and the subsequent vesicle trafficking processes.
The interaction of Rab 4B activators with their target protein involves a conformational change that stabilizes the GTP-bound form of Rab 4B, thereby increasing its affinity for effectors that mediate vesicular transport. By enhancing the activity of Rab 4B, these activators can influence the rate and specificity of vesicular trafficking within cells. This has implications for the dynamic remodeling of the cell surface, including the composition of proteins and receptors available for various cellular signaling pathways. Since the Rab 4B protein is a key regulator in the recycling of vesicles, its activators therefore play a significant role in maintaining the balance and flux of cellular components necessary for cell function and homeostasis.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720 modulates sphingosine-1-phosphate receptors (S1P-R), particularly S1P-R1, leading to downstream signaling events. This activation enhances Rab4b activity by promoting its recruitment to endosomal membranes, thereby facilitating endosome maturation and intracellular trafficking. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Erythromycin activates Rab4b by interacting with specific G-protein-coupled receptors (GPCRs) on the cell surface. This interaction triggers signaling pathways that ultimately result in Rab4b activation. The precise GPCRs involved can vary depending on cell type. | ||||||
Adenosine phosphate(Vitamin B8) | 61-19-8 | sc-278678 sc-278678A | 50 g 100 g | $160.00 $240.00 | ||
AMP activates Rab4b by increasing the levels of cyclic AMP (cAMP) within the cell. Elevated cAMP levels activate protein kinase A (PKA), which subsequently phosphorylates Rab4b, enhancing its activity in endocytic pathways. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 increases intracellular calcium levels by acting as a calcium ionophore. Elevated calcium levels initiate various signaling cascades, including those involving calmodulin and protein kinases, ultimately leading to Rab4b activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable analog of cAMP. It activates protein kinase A (PKA) directly, which in turn phosphorylates Rab4b, leading to increased Rab4b activity in regulating endocytic processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Rab4b by activating protein kinase C (PKC), specifically PKC isoforms like PKCα. PKC phosphorylates Rab4b, enhancing its role in membrane trafficking and recycling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum calcium ATPase (SERCA) pump, causing a sustained increase in intracellular calcium levels. Elevated calcium levels lead to Rab4b activation, facilitating endosome maturation and trafficking. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates Rab4b by binding to insulin receptors on the cell surface. This initiates downstream signaling cascades, including the PI3K-AKT pathway. Akt phosphorylates Rab4b, enhancing its involvement in insulin-stimulated glucose transporter translocation. | ||||||
D-erythro-Sphingosine | 123-78-4 | sc-3546 sc-3546A sc-3546B sc-3546C sc-3546D sc-3546E | 10 mg 25 mg 100 mg 1 g 5 g 10 g | $90.00 $194.00 $510.00 $2448.00 $9384.00 $15300.00 | 2 | |
Sphingosine activates Rab4b by regulating sphingosine-1-phosphate receptors (S1P-Rs). Upon S1P-R activation, downstream signaling pathways are initiated, leading to Rab4b activation and facilitating endocytic processes. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine activates Rab4b through dopamine receptor-mediated intracellular signaling. The specific receptor subtype activated can vary, but it typically involves G-protein-coupled receptor (GPCR) signaling pathways that modulate Rab4b activity in synaptic vesicle recycling. | ||||||