Rab 4B Antibody (C-3): sc-271982

Rab 4B Antibody (C-3) is a mouse monoclonal IgM kappa antibody that detects the Rab 4B protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Rab 4B antibody (C-3) is available as a non-conjugated format, providing researchers with a reliable tool for studying this critical protein. Rab 4B is a member of the Ras-related superfamily of guanine nucleotide-binding proteins, which plays a pivotal role in intracellular transport processes. Specifically, Rab 4B is involved in the regulation of endocytosis and the transport of newly synthesized proteins from the endoplasmic reticulum to the Golgi apparatus and ultimately to secretory vesicles. This transport is essential for maintaining cellular function and homeostasis, as proteins reach their correct destinations within the cell. The ability of Rab proteins to facilitate the movement of carrier vesicles is crucial for the proper functioning of the secretory pathway, and evidence suggests that Rab proteins may also be involved in directing exocytosis from secretory vesicles to the plasma membrane. Understanding the dynamics of Rab 4B and its interactions within the cellular transport system can provide insights into various physiological processes and potential pathological conditions, making Rab 4B (C-3) antibody an invaluable resource for researchers in the field.

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Rab 4B Antibody (C-3) References:

1. The complexity of the Rab and Rho GTP-binding protein subfamilies revealed by a PCR cloning approach.  |  Chavrier, P., et al. 1992. Gene. 112: 261-4. PMID: 1555775
2. Cloning of a Rab3 isotype predominantly expressed in adipocytes.  |  Baldini, G., et al. 1992. Proc Natl Acad Sci U S A. 89: 5049-52. PMID: 1594612
3. The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion.  |  Zahraoui, A., et al. 1989. J Biol Chem. 264: 12394-401. PMID: 2501306
4. Golgi-associated retrograde protein (GARP) complex-dependent endosomes to trans Golgi network retrograde trafficking is controlled by Rab4b.  |  Gilleron, J., et al. 2024. Cell Mol Biol Lett. 29: 54. PMID: 38627612
5. Host Factor Rab4b Promotes Japanese Encephalitis Virus Replication.  |  Zhao, Q., et al. 2024. Microorganisms. 12: PMID: 39338478
6. RAB4B and Japanese encephalitis virus E protein interaction is essential for viral entry in early endosomes.  |  Miao, C., et al. 2025. Int J Biol Macromol. 306: 141452. PMID: 40020812
7. Expression and localization of two low molecular weight GTP-binding proteins, Rab8 and Rab10, by epitope tag.  |  Chen, YT., et al. 1993. Proc Natl Acad Sci U S A. 90: 6508-12. PMID: 7688123
8. Coatomers and SNAREs in promoting membrane traffic.  |  Takizawa, PA. and Malhotra, V. 1993. Cell. 75: 593-6. PMID: 8242734
9. Friends and family: the role of the Rab GTPases in vesicular traffic.  |  Novick, P. and Brennwald, P. 1993. Cell. 75: 597-601. PMID: 8242735
10. The role of GTP-binding proteins in transport along the exocytic pathway.  |  Ferro-Novick, S. and Novick, P. 1993. Annu Rev Cell Biol. 9: 575-99. PMID: 8280472
11. Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation.  |  Torti, M., et al. 1993. Proc Natl Acad Sci U S A. 90: 7553-7. PMID: 8356055
12. Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins.  |  Karniguian, A., et al. 1993. Proc Natl Acad Sci U S A. 90: 7647-51. PMID: 8356066

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Rab 4B Antibody (C-3) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Rab 4B Antibody (C-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Rab 4B Antibody (C-3) Specifications

Alternate Product Name: Rab 4B

Product Clone Name: C-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 197-213

Epitope Target: Rab 4B

Epitope Species: human

Product Reactivity/Detection: Rab 4B

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Rab 4B Antibody (C-3): P: Blocking Peptide

The preferred Rab 4/14 antibody is Rab 4/14 Antibody (F-10): sc-376243.