Date published: 2026-3-31

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PVRIG Activators

PVRIG Activators comprise a diverse group of chemicals that can influence the activity of the PVRIG protein, a receptor playing an integral role in the immune system, specifically within the realm of T cell response. These activators work by impacting various pathways or processes that relate to or surround PVRIG's functionality.

A notable example from this class is Phorbol Myristate Acetate (PMA), a compound recognized for its capability to activate protein kinase C, a key player in T cell activation processes. In tandem, Ionomycin can raise intracellular calcium levels, acting as a complementary force to PMA in driving T cell activation, which in turn affects PVRIG's function. On the other hand, substances like Cyclosporin A modulate T cell activation, casting implications on proteins like PVRIG. The list also features specialized inhibitors such as Okadaic Acid, Bisindolylmaleimide I, LY294002, U0126, Wortmannin, PD98059, and SB203580. Each of these compounds holds the power to target and inhibit specific enzymes or pathways central to T cell signaling.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA can activate protein kinase C, which is involved in T cell activation processes. This can indirectly influence PVRIG function.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$78.00
$270.00
80
(4)

Ionomycin raises intracellular calcium levels, complementing the action of PMA in T cell activation, potentially affecting PVRIG's role.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$63.00
$92.00
$250.00
$485.00
$1035.00
$2141.00
69
(5)

An immunosuppressive agent that inhibits T cell activation, indirectly affecting proteins like PVRIG.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Inhibits mTOR, a key component in T cell activation. This can have implications for proteins like PVRIG.

Okadaic Acid

78111-17-8sc-3513
sc-3513A
sc-3513B
25 µg
100 µg
1 mg
$291.00
$530.00
$1800.00
78
(4)

A serine/threonine phosphatase inhibitor which can influence T cell signaling, potentially modulating PVRIG's activity.

Bisindolylmaleimide I (GF 109203X)

133052-90-1sc-24003A
sc-24003
1 mg
5 mg
$105.00
$242.00
36
(1)

A protein kinase C inhibitor that affects T cell activation and can indirectly modulate PVRIG function.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

A PI3K inhibitor that can modulate T cell signaling and, by extension, potentially affect PVRIG activity.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$67.00
$223.00
$425.00
97
(3)

Another PI3K inhibitor which can impact T cell activation, having potential implications for PVRIG.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

Inhibits the activation of MAPK, which is involved in T cell signaling, and can indirectly influence PVRIG.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$90.00
$349.00
284
(5)

A p38 MAPK inhibitor, which modulates T cell activation processes and can indirectly affect PVRIG activity.